Integrin subunits

Beta-4 integrin subunit

Factsheet

Human

Cys-rich domains 4

N-glycos. sites 5

Conserved cysteines 48

Total cysteines 48 + 16c

Pred. mw from sequence 195

Size (non reduced) 200

Size (reduced) 205

Number of aa 1752 (1805) (1822)

Number of aa cyto domain 1019 (1072) (1089)

Size mRNA 6

Chromosome 17q11-qter

The beta-4 subunit is also known as CD104, and is expressed on epithelia, Schwann cells, neuronal cells and trophoblasts. This integrin subunit can form a heterodimer with the alpha-6 subunit.

There is a knockout mouse for this integrin subunit (van der Neut et al., 1996. Nature Genet. 13, 366-369). Mice that lack this subunit die soon after birth and lack hemidesmosomes, which leads to severe blistering of the skin.

Amino acid sequences of cytoplasmic domain

The sequences of the cytoplasmic domains for this subunit are too large to depict here.

Genbank sequences (EMBL) which exist for this integrin subunit

Accession # Description Reference

X53587 Human beta-4 mRNA. Tamura et al., 1990. J. Cell Biol. 111, 1593-1604

U60096 Rat beta-4 mRNA. Complete coding sequence. Feltri et al., 1994. Development 120, 1287-1301

Antibody's against beta-4 subunit

Name Against Species Type Reference

346-11A Beta-4 (mouse) Rat Mono Kennel et al., 1989. J. Biol. Chem. 264, 15515-15121 Yes

439-9B Beta-4 (human) Rat Mono Kennel et al., 1989. J. Biol. Chem. 264, 15515-15121 Yes

450-9D Beta-4 (human) Mouse Mono Kennel et al., 1990. Hybridoma 9, 243-255 Yes

450-10D Beta-4 (human/rat) Mouse Mono Kennel et al., 1990. Hybridoma 9, 243-255

4.3E1 Beta-4 (human) Mouse Mono Reference

2150-11A Beta-4 (human) Mouse Mono Reference

67 Beta-4 (human?/rat/mouse) c Rabbit Type Reference

ASC-3 Beta-4 (human) Mouse Mono Reference

ASC-4 Beta-4 Mouse Mono Reference

ASC-8 Beta-4 Mouse Mono Reference

ASC-9 Beta-4 Mouse Mono Reference

UM-A9 Beta-4 (human) Mouse Mono van Waes et al., 1991. Cancer Res. 51, 2395-2402

AA3 Beta-4 (human) Mouse Mono Tamura et al., 1990. J. Cell. Biol. 111, 1593-1604

450-11A Beta-4 (hu) Mouse Mono Reference Yes

Last updated on 18/06/97
© 1997 jkoster@hotmail.com

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	Human
Cys-rich domains	4
N-glycos. sites	5
Conserved cysteines	48
Total cysteines	48 + 16c
Pred. mw from sequence	195
Size (non reduced)	200
Size (reduced)	205
Number of aa	1752 (1805) (1822)
Number of aa cyto domain	1019 (1072) (1089)
Size mRNA	6
Chromosome	17q11-qter

Accession #	Description	Reference
X53587	Human beta-4 mRNA.	Tamura et al., 1990. J. Cell Biol. 111, 1593-1604
U60096	Rat beta-4 mRNA. Complete coding sequence.	Feltri et al., 1994. Development 120, 1287-1301

Name	Against	Species	Type	Reference
346-11A	Beta-4 (mouse)	Rat	Mono	Kennel et al., 1989. J. Biol. Chem. 264, 15515-15121	Yes
439-9B	Beta-4 (human)	Rat	Mono	Kennel et al., 1989. J. Biol. Chem. 264, 15515-15121	Yes
450-9D	Beta-4 (human)	Mouse	Mono	Kennel et al., 1990. Hybridoma 9, 243-255	Yes
450-10D	Beta-4 (human/rat)	Mouse	Mono	Kennel et al., 1990. Hybridoma 9, 243-255
4.3E1	Beta-4 (human)	Mouse	Mono	Reference
2150-11A	Beta-4 (human)	Mouse	Mono	Reference
67	Beta-4 (human?/rat/mouse) c	Rabbit	Type	Reference
ASC-3	Beta-4 (human)	Mouse	Mono	Reference
ASC-4	Beta-4	Mouse	Mono	Reference
ASC-8	Beta-4	Mouse	Mono	Reference
ASC-9	Beta-4	Mouse	Mono	Reference
UM-A9	Beta-4 (human)	Mouse	Mono	van Waes et al., 1991. Cancer Res. 51, 2395-2402
AA3	Beta-4 (human)	Mouse	Mono	Tamura et al., 1990. J. Cell. Biol. 111, 1593-1604
450-11A	Beta-4 (hu)	Mouse	Mono	Reference	Yes