| Human | |
| I-domain | No |
| N-glycos. sites | 9 |
| Conserved cysteines | 18 |
| Total cysteines | 19 + 1c |
| Pred. mw from sequence | 117 |
| size (non reduced) | 150 |
| Size (reduced) | 130 + 30 |
| Metal binding sites | 3 |
| Number of aa | 1050 (1068) |
| Number of aa cyto domain | 36 (54) |
| Size mRNA | 6 |
| Chromosome | 2 |
The alpha-6 subunit is also known as CD49f. For this integrin subunit there is a knockout mouse available. Mice lacking this subunit show perinatal lethality, with blistering of the skin ( Georges-Labouesse et al., 1996. Nat. Genet. 13, 370-373 ). This is the same phenotype as observed in beta-4 knockout mice.
| Alpha-6A human | KCGFFKRNKKDHYDATYHKAEIHAQPSDKERLTSDA |
| Alpha-6A mouse | KCGFFKRNKKDHYDATYHKAEIHTQPSDKERLTSDA |
| Alpha-6A chick | KCGFFKRSKKDHYDATYHKAEIHAQPSDKERLTSDA |
| Alpha-6A Xenopus | KCGFFRRDKKDQFDATYHKAEIHAQPSDKERLTSDA |
| Alpha-6B human | KCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWNRNESYS |
| Alpha-6B mouse | KCGFFKRSRYDDSIPRYHAVRIRKEEREIKDEKHMDNLEKKQWITKWNENESYS |
| Alpha-6B chick | KCGFFQRSRYDDSVPRYHAVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx |
| Alpha-6B Xenopus | KCGFFKRSRYDDSIPRYHAVRIPKEEREYKDGKLPKNSEKKQWVTKWNENESYS |
| Accession # | Description | Reference |
| X53586 | Human alpha-6 mRNA. Complete coding sequence | Tamura et al., 1990. J. Cell Biol. 111, 1593-1604 |
| L35051 | Xenopus alpha-6 mRNA. Partial coding sequence | Lallier et al., 1996. Development 122, 2539-2554 |
| Name | Against | Species | Type | Reference | Com. |
| J8H | Alpha-6A (hu) c | Mouse | Mono | Delwel et al., 1994. Mol. Biol. Cell. 5, 203-215 | |
| GoH3 | Alpha-6 (hu/ms) | Rat | Mono | Sonnenberg et al., 1988. Nature 336, 487-489 | Yes |
| 450-33D | Alpha-6 (hu) | Mouse | Mono | Kennel et al., 1990. Hybridoma 8, 243-255 | |
| PAlpha6A | Alpha-6A c | Rabbit | Poly | Delwel et al., 1993. J. Biol. Chem. 268, 25865-25875 | |
| 1A10 | Alpha-6A (ms) c | Mouse | Mono | Hogervorst et al., 1993. J. Cell. Biol. 121, 179-191 | |
| 6B4 | Alpha-6B c | Mouse | Mono | Hogervorst et al., 1993. J. Cell. Biol. 121, 179-191 | |
| BQ-16 | Alpha-6 (hu) | Mouse | Mono | Liebert et al., 1993. Hybridoma. 12, 67-80 | |
| P2C62C4 | Alpha-6 (chicken) | Mouse | Mono | Development. 115, 197-211 | |
| LB-701 | Alpha-6 (hu) | Rat | Mono | Reference | yes |
| 4F10 | Alpha-6 (hu) | Mouse | Mono | Reference | Yes |
