Alpha-M / Beta-2 integrin

AlphaM/beta2 is a receptor for C3bi (inactivated form of C3b), factor X (coagulation factor X), fibrinogen and ICAM-1 (intercellular adhesion molecule 1). It is expressed on monocytes, macrophages, NK cells and granulocytes. Alpha-M/beta-2 is important in adherence of monocytes and neutrophils to vascular endothelium, as well as in sebsequent extravasation. It also plays a role in phagocytosis of complement coated particles. This integrin is also known as Mac-1 (macrophage receptor 1) and CR-3 (C3bi receptor).

Last updated on 18/06/97

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