Dr. Arnoud Sonnenberg

E-mail:asonn@nki.nl

Publications

Feltkamp, C.A., Wilschut, I.J.C., van Blitterswijk, W.J., Hilgers, J., and Sonnenberg, A. Modulation of virus-induced tumor antigens (MLr) on murine leukemia cells. In: Advances in comparative leukemia research. Bentvelzen et al. (eds.) Elsevier, North-Holland Biomedical Press, pp. 345-348 (1978).

Hilgers, J., Sonnenberg, A., and Nusse, R. Antigenic modulation of mammary tumor virus envelope antigen on GR thymiclymphoa cells in relation to expression of H-2, TL cell-surface antigens and Thy1. Br. J. Cancer 42:542-550 (1980).

Sonnenberg, A., Dulbecco, R., and Okada, S. Tumor promoter binding to rat mammary cell cultures: Role of receptors in the inhibition of dome formation. Cancer Res. 43:1059-1065 (1983).

Sonnenberg, A., Kolvenbag, G.J.C.M., Al, E.J.M., and Hilgers, J. Molecular characterization of a membrane protein by a simple immunobinding procedure with monoclonal antibodies. J. Immunol. Methods 72:443-450 (1984).

Hilkens, J., Buijs, F., Hilgers, J., Hageman, Ph., Calafat, J., Sonnenberg, A., and van der Valk, M. Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors. Int. J. Cancer 34:197-206 (1984).

Sonnenberg, A., Daams, H., van der Valk, M.A., Hilkens, J., and Hilgers, J. Development of the mouse mammary gland; identification of stages in the differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin. J. Histochem. Cytochem. 34:1037-1046 (1986).

Sonnenberg, A., van Balen, P., Hengeveld, T., Kolvenbag, G.J.C.M., van Hoeven, R.P., and Hilgers, J. Monoclonal antibodies detecting different epitopes on the Forssman glycolipid hapten. J. Immunol. 137:1264-1269 (1986).

Sonnenberg, A., Daams, H., Calafat, J., and Hilgers, J. In vitro differentiation and progression of mouse mammary tumor cells. Cancer Res. 46:5913-5922 (1986).

Mareel, M.M., de Bruyne, G.K., Sonnenberg, A., and Hilgers, J. Experimental results on invasiveness of mouse mammary cells: Clinical implications? In: New Frontiers in mammary pathology. K.H. Hollman and J.M. Verley (eds.). Boston/Dordrecht/Lancaster: Martinus Nijhoff publishers, pp. 351-362 (1986).

Daams, J., Sonnenberg, A., Sakakura, T., and Hilgers, J. Changes in antigen patterns during development of the mouse mammary gland: Implications for tumorigenesis. In: Cellular and molecular biology of mammary cancer. D. Medina, W. Kidwell, G. Heppner and E. Anderson (eds.). Plenum Publishing Corporation, pp. 1-8 (1987).

Hilgers, J., and Sonnenberg, A. Viral and nonviral mammary tumorigenesis. In: Retroviruses and human pathology. R. Gallo, D. Stehelin and O. Varnier (eds.). Clifton, New Jersey: The Human Press, Inc. pp. 87-97 (1987).

Sonnenberg, A., van Balen, P., Hilgers, J., Schuuring, E., and Nusse, R. Oncogene expression during progression of mouse mammary tumor cells: activity of a proviral enhancer and the resulting expression of int-2 is influenced by the state of differentiation. EMBO J. 6:121-125 (1987).

Rijsewijk, F., van Deemter, L., Wagenaar, E., Sonnenberg, A., and Nusse, R. Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorgenicity. EMBO J. 6:127-131 (1987).

Nusse, R., van Ooyen, A., and Sonnenberg, A. Activation of the cellular oncogenes int-1 and int-2 by proviral insertion of the mouse mammary tumor virus. In: Viral Carcinogenesis. N.O. Kjelgaard and J. Forchhammer (eds.). Munksgaard, Copenhagen pp. 225-237 (1987).

Sonnenberg, A., Janssen, H., Hogervorst, F., Calafat, J., and Hilgers, J. A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody. J. Biol. Chem. 262:10376-10383 (1987).

Hemler, M.E., Crouse, C., Takada, Y., and Sonnenberg, A. Multiple VLA heterodimers on platelets: Evidence for distinct VLA-2, VLA-5 (fibronectin receptor) and VLA-6 structures. J. Biol. Chem. 263:7660-7665 (1988).

Sonnenberg, A., Hogervorst, F., Osterop, A., and Veltman, F.E.M. Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic. J. Biol. Chem. 263:14030-14038 (1988).

Sonnenberg, A., Daams, J., Delemare, F., Lens, P., and Hilgers, J. Immunological markers in the study of the development of the mouse mammary gland and its tumors. In: Breast cancer: Scientific and Clinical Progress. M.A. Rich, J.C. Hager, and D.M. Lopez (eds.). Kluwer Academic Publisher, pp. 88-111 (1988).

Sonnenberg, A., Modderman, P.W., and Hogervorst, F. Laminin receptor on platelets is the integrin VLA-6. Nature 336:487-489 (1988).

Cato, A.C.B., Weinmann, J., Mink, S., Ponta, H., Henderson, D., and Sonnenberg, A. The regulation of expression of mouse mammary tumor virus DNA by steroid hormones and growth factors. J. Steroid Biochem. 34:139-143 (1989).

Hemler, M.E., Crouse, C., and Sonnenberg, A. Association of the VLA alpha-6 subunit with a novel protein: A possible alternative to the common VLA beta-1 subunit on certain cell lines. J. Biol. Chem. 264:6529-6535 (1989).

Kennel, S.J., Foote, L.J., Falcioni, R., Sonnenberg, A., Stringer, C.D., Crouse, C., and Hemler, M.E. Analysis of the tumor associated antigen TSP-180: Identity with alpha-6-beta-4 in the integrin superfamily. J. Biol. Chem. 264:15515-15521 (1989).

Modderman, P.W., von dem Borne, A.E.G. Kr., and Sonnenberg, A. VLA-2, VLA-6 and GPIIb/IIIa function as activation-independent platelet adhesion receptors for collagen I, laminin, and fibrinogen, respectively. Leukocyte Typing IV, Oxford University Press, pp. 1035-1036 (1989).

Aumailley, M., Gerl, M., Sonnenberg A., Deutzman, R., and Timpl, R. Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1. FEBS Lett. 262:82-86 (1990).

Aumailley, M., Timpl, R., and Sonnenberg, A. Antibody to integrin alpha-6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188:55-60 (1990).

Cato, A.C.B., Mink, S., Nierlich, B., Ponta, H., Schaap, D., Schuuring, E., and Sonnenberg, A. Transforming growth factor-beta represses transcription of the mouse mammary tumor virus DNA in cultured mouse mammary cells. Oncogene 5:103-110 (1990).

Goldschmeding, R., Dolman, K.M., van den Ende, M.E., van der Meer-Gerritsen, C.H., Sonnenberg, A., von dem Borne, A.E.G.Kr. The relation of 29kD c-ANCA antigen to proteinase 3. APMIS Suppl. 19:98 (1990).

Hall, D.E., Reichardt, L.F., Crowley, E., Holley, B., Moezzi, H., Sonnenberg, A., and Damsky, C.H. The alpha1/beta1 and alpha6/beta1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J. Cell Biol. 110:2175-2184 (1990).

Hogervorst, F., Kuikman, I., von dem Borne, A.E.G. Kr., and Sonnenberg, A. Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kDa cytoplasmic domain. EMBO J. 9:765-770 (1990).

Schuuring, E., van der Leede, B.J., Willems, R., Daams, H., van der Valk, M., van de Vijver, M., van Leeuwen, F., Sonnenberg, A., and Nusse, R. Differentiation-dependent expression of provirus-activated int-1 oncogene in clonal cell lines derived from a mouse mammory tumor. Oncogene 5:459-465 (1990).

Sonnenberg, A., Linders, C.J.T., Daams, J.H., and Kennel, S.J. The alpha6beta1 (VLA-6) and alpha6beta4 protein complexes: Tissue distribution and biochemical properties. J. Cell Sci. 96:207-217 (1990).

Sonnenberg, A., Linders, C.J.T., Modderman, P.W., Damsky, C.H., Aumailley, M., and Timpl, R. Integrin recognition of different cell binding fragments of laminin (P1, E3 and E8) and evidence that alpha6beta1 but not alpha6beta4 functions as a specific receptor for E8. J. Cell Biol. 110:2145-2155 (1990).

Sorokin, L., Sonnenberg, A., Aumailley, M., Timpl, R., and Ekblom, P. Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha6 subunit is essential for epithelial polarization in developing kidney tubules. J. Cell Biol. 111:1265-1273 (1990).

Butor, C.M.B., Stelzer, E.H.K., Sonnenberg, A., and Davoust J. Apical and basal forssman antigen in MDCK II cells: A morphological and quantitative study. Eur. J. Cell Biol. 56:269-285 (1991).

von der Mark, H., Dürr, J., Sonnenberg, A., von der Mark, K., Deutzmann, R., and Goodman, S.L. Skeletal myoblasts utilize a novel b1-series integrin, and not alpha6beta1 for binding to the E8 and T8 fragments of laminin. J. Biol. Chem. 266:23593-23601 (1991).

Sonnenberg, A., Modderman, P.W., van der Geer, P., Aumailley, M., and Timpl, R. Structure and function of platelet glycoprotein Ic-IIa (VLA-6). In: Platelet Immunology: fundamental and clinical aspects. C. Kaplan, N. Schlegel, Ch. Salmon and J.McGregor (eds.). Colloque INSERM/John Libbey Eurotext Ltd. 206:75-95 (1991).

Sonnenberg, A., Calafat, J., Janssen, H., Daams, H., Kennel, S.J., Aplin, J.D., Baker, J., Loizidou, M., and Garrod, D. Integrin alpha6/beta4 complex is located in hemidesmosomes suggesting a major role in epidermal cell-basement membrane adhesion. J. Cell Biol. 113:907-917 (1991).

Hogervorst, F., Kuikman, I., Geurts van Kessel, A., and Sonnenberg A. Molecular cloning of the human alpha6 integrin subunit. Alternative splicing of a6 mRNA and chromosomal localization of the a6 and b4 genes Eur. J. Biochem. 199:425-433 (1991)

Sonnenberg, A., Gehlsen, K.R., Aumailley, M., and Timpl, R. Isolation of alpha6beta1 integrins from platelets and adherent cells by affinity chromatography on mouse laminin fragment E8 and human laminin pepsin fragment. Exp. Cell Res. 197:234-244 (1991).

Hindriks, G., IJsseldijk, M.J.W., Sonnenberg, A., Sixma, J.J., and de Groot, Ph.G. Platelet adhesion to laminin: Role of Ca2+ and Mg2+-ions, shear rate and platelet membrane glycoproteins. Blood 79:928-935 (1992).

Modderman, P.W., Admiraal, L.G., Sonnenberg, A., and von dem Borne, A.E.G. Kr. Glycoproteins GPV and GPIb/IX form a noncovalent complex in the platelet membrane. J. Biol. Chem. 267:364-369 (1992).

de Bruijne-Admiraal, L.G., Modderman, P.W., von dem Borne, A.E.G. Kr., and Sonnenberg, A. P-Selectin mediates Ca2+-dependent adhesion of activated platelets to many different types of leukocytes: detection by flow cytometry. Blood 80:134-142 (1992).

Dolman, K.M, van de Wiel, B.A., Kam, C-M., Abbink, J.J., Hack, C.E., Sonnenberg A., Powers, J.C., von dem Borne, A.E.G., and Goldschmeding, R. Determination of proteinase 3-a-antitrypsin complexes in inflammatory fluids. FEBS Lett. 314:117-121 (1992).

Sonnenberg A. Laminin receptors in the integrin family Path Biol. 40:773-778 (1992).

Jonkman, M.T., de Jong, M.C.J.M., Heeres, K., and Sonnenberg, A. Expression of integrin alpha6beta4 in Junctional Epidermolysis Bullosa J. Invest. Dermat. 99:489-496 (1992).

Dolman, K.M., Damsma, I., Tool, A.T.J., Sonnenberg, A., von dem Borne, A.E.G.Kr., and Goldschmeding, R. A novel specificity of anticytoplasmic autoantibodies directed against eosinophil peroxidase. Clin. Exp. Immunol. 92:58-64 (1993).

Hogervorst, F., Admiraal, L.G., Niessen, C., Kuikman, I., Janssen, H., Daams, H., and Sonnenberg, A. Biochemical characterization and tissue distribution of the A and B variants of the alpha6 integrin subunit. J. Cell Biol. 121:179-191 (1993).

Hierck, B.P., Thorsteinsdottir, S., Niessen, C.M., Freund, E., van Iperen, L.V., Feyen, A., Hogervorst, F., Poelmann, R.E., Mummery, C.L., and Sonnenberg, A. Variants of the alpha6beta1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin a6 subunit. Cell Adhes. Commun. 1:33-53 (1993).

Ruiz, P., Dunon, D., Sonnenberg, A., and Imhof, B.A. Suppresion of mouse melanoma metastasis by EA-1, a monoclonal antibody specific for alpha6 integrins. Cell Adhes. Commun. 1:67-81 (1993).

Hogervorst, F., Kuikman, I., Noteboom, E., and Sonnenberg, A. The role of phosphorylation in activation of the alpha6Abeta1 laminin receptor. J. Biol. Chem. 268:18427-18430 (1993).

Delwel, G.O., Hogervorst, F., Kuikman, I., Paulsson, M., Timpl, R., and Sonnenberg, A. Expression and function of the cytoplasmic variants of the integrin alpha6 subunit in transfected K562 cells. J. Biol. Chem. 268:25865-25875 (1993).

Sonnenberg, A. Integrins and their ligands. In: Current topics in Microbiology and Immunology. D. Dunon, C.R. Mackay and B.A. Imhof (eds). Springer-Verlag GmbH Co. Heidelberg. Vol. 184:7-35 (1993).

Dofuku, R., Sonnenberg, A., and Hilgers, J. Role of the gene on trisomic and pentasomic chromosome 13 in murine mammary tumorigenesis. Cancer Genetics and Cytogenetics 69:100-107 (1993).

Sonnenberg, A., de Melker, A.A., Martinez de Velasco, A.M., Janssen, H., Calafat, J., and Niessen, C.M. Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin. J. Cell Sci. 106:1083-1102 (1993).

Durban, E.M., Barreto, P.D., Hilgers, J., and Sonnenberg, A. Cell phenotypes and differentiative transitions in mouse submandibular salivary gland defined with monoclonal antibodies to mammary epithelial cells. J. Histochem. Cytochem. 42:185-196 (1994).

Niessen, C.M., Cremona, O., Daams, H., Ferraresie, S., Sonnenberg, A. and Marchisio, P.C. Expression of the integrin alpha6beta4 in peripheral nerves: localization in Schwann cells and perineural cells and different variants of the beta4 subunit. J. Cell Sci. 107:543-552 (1994).

Delwel, G.O., de Melker, A.A., Hogervorst, F., Jaspars, L.H., Fles, D.L.A., Kuikman, I., Lindblom, A., Paulsson, M., Timpl, R., and Sonnenberg, A. Distinct and overlapping ligand specificities of the alpha3Abeta1 and alpha6Abeta1 integrins: recognition of laminin isoforms. Mol. Biol. Cell. 5:203-215 (1994).

Uematsu, J., Nishizawa, Y., Sonnenberg, A., and Owaribe, K. Demonstration of type II hemidesmosomes in a mammary gland epithelial cell line, BMGE-H. J. Biochem. 115:469-476 (1994).

Niessen, C.M., Hogervorst, F., Jaspars, L.H., de Melker, A.A., Delwel, G.O., Hulsman, E.H.M., Kuikman, I., and Sonnenberg, A. The alpha6beta4 integrin is a receptor for both laminin and kalinin. Exp. Cell Res. 211:360-367 (1994).

Modderman, P.W., von dem Borne, A.E.G.Kr., and Sonnenberg, A. Tyrosine phosphorylation of P-selectin in intact platelets and in a disulphide-linked complex with immunoprecipiated pp60c-src. Biochem. J. 299: 613-621 (1994).

Kemperman, H., Wijnands, Y., Wesseling, J., Niessen, C.M., Sonnenberg, A., and Roos, E. The mucin epiglycanin on TA3/Ha carcinoma cells prevents alpha6beta4-mediated adhesion to laminin and kalinin and E-cadherin mediated cell-cell interaction. J. Cell Biol. 127: 2071-2080 (1994).

Gimond, C., de Melker, A., Aumailley, M., and Sonnenberg, A. The cytoplasmic domain of alpha6A integrin subunit is an in vitro substrate for protein kinase C. Exp. Cell Res. 216: 232-235 (1995).

Jonkman, M.F., de Jong, M.C.J.M., Heeres, K., Pas, H.H., van der Meer, J.B., Owaribe, K., Martinez de Velasco, A.M., Niessen, C.M., and Sonnenberg, A. The 180-kD Bullous Pemphigoid Antigen (BP180) is deficient in Generalized Atrophic Benign Epidermolysis Bullosa. J. Clin. Invest. 95: 1345-1352 (1995).

Delwel, G.O., and Sonnenberg, A. Laminin isoforms and their integrin receptors. In: Adhesion receptors as therapeutic targets. M.A. Horton (ed.) CRC press, Inc., pp 8-36 (1995).

Wesseling, J., van der Valk, S., Vos, H.L., Sonnenberg, A., and Hilkens, J. Epsialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J. Cell Biol. 129: 255-265 (1995).

Delwel, G.O., Kuikman, I, and Sonnenberg, A. An alternative spliced exon in the extracellular domain of the human alpha6 integrin subunit. Functional analysis of the a6 integrin variants. Cell Adhes. Commun. 3: 143-161 (1995).

Patriarca, C., Ivanyi, D., Fles, D.L.A., de Melker, A. A., van Doornewaard, G., Oomen, L., Alfano, R M., Coggi, G., and Sonnenberg, A. Distributionof extracellular and cytoplasmic domains of the integrin alpha3 and alpha6 subunits in solid tumors. Int. J. Cancer 63: 182-189 (1995).

Almeida, E.A.C., Huovila, A.-P.J., Sutherland, A.E., Stephens, L.E., Calarco, P.G., Sonnenberg, A., Shaw, L.M., Mercurio, A.M., Primakoff, A., Myles, D.G., and White, J.M. Mouse egg integrin alpha6beta1 functions as a sperm receptor. Cell 81: 1095-1104 (1995).

Aten, J., Veninga, A., Coers, W., Sonnenberg, A., Timpl, R., Claessen, N., van Eendenburg, J.D.H., de Heer, E., and Weening, J.J. Autoantibodies to the laminin P1-fragment in HgCl2-induced membranous glomerulopathy. Am. J. Pathol. 146: 1467-1480 (1995).

van der Flier, A., Kuikman, I., Baudoin, C., van der Neut, R., and Sonnenberg. A novel beta1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle. FEBS letters 369: 340-344 (1995).

Thorsteinsdóttir, S., Roelen, B.A.J., Freund. E., Gaspar, A.C., Sonnenberg, A., and Mummery, C. Expression of laminin receptor splice variants alpha6Abeta1 and alpha6Bbeta1 suggest different roles in mouse development. Develop. Dynamics 204: 240-258 (1995).

Sonnenberg, A., Jonkman, M., Delwel, G.O., Gimond, C., Martinez de Velasco, A.M., de Melker, A.A., van der Neut, R., and Niessen, C.M. Intracellular and extracellular functions of the alpha6beta1 and a6b4 integrins. Proceedings of the 7th International Symposium on Basement Membranes. National Institute of Health, Bethesda, Maryland, 117-136 (1996).

Jonkman, M.F., de Jong, M.C.J.M., Heeres, K., Steijlen, P.M., Owaribe, K., Küster, W., Meurer, M., Gedde-Dahl, T., Sonnenberg, A., and Bruckner-Tuderman, L. Generalized Atrophic Benign Epidermolysis Bullosa. Either 180-kD Bullous Pemphigoid Antigen (BP180) or laminin-5 deficiency. Arch. Dermatol. 132: 145-150 (1996).

Delwel, G.O., Hogervorst, F., and Sonnenberg, A. Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by PMA. J. Biol. Chem. 271: 7293-7296 (1996).

Baudoin, C., van der Flier, A., Borradori, L., and Sonnenberg, A. Genomic organization of the mouse b1 gene: Conservation of the beta1D but not of the beta1B and beta1C integrin splice variants. Cell Adhes. Commun. 4: 1-11 (1996).

Van der Neut, R., Krimpenfort, P., Calafat, J., Niessen, C.M., and Sonnenberg A. Epithelial detachment due to absence of hemidesmosomes in integrin beta4 null mice. Nature Genet. 13, 366-369 (1996).

Niessen, C.M., van der Raaij-Helmer, L.M.H., Hulsman, E.H.M., van der Neut, R., Jonkman, M.F., and Sonnenberg, A. Deficiency of the integrin beta4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J. Cell Sci. 109: 1695-1706 (1996).

Borradori, L., and Sonnenberg, A. Hemidesmosomes: role in adhesion, signaling and human diseases. Curr. Opin. Cell Biol. 8: 647-656 (1996)

De Melker, A.A., and Sonnenberg, A. The role of the cytoplasmic domain of the alpha6 integrin subunit in the assembly and function of alpha6beta1 and alpha6beta4. Eur. J. Biochem. 241: 254-264 (1996).

Jaspars, L.H., de Melker, A.A., Bonnet, P., Sonnenberg, A., and Meijer, C.J.L.M. Distribution of laminin variants and their integrin receptors in human secondary lymphoid tissue. Colocalization suggests that the alpha6beta4 integrin is a receptor for laminin-5 in lymphoid tissue. Cell Adhes. Commun. 4: 269-279 (1996).

Sánchez-Aparicio, P., Martínez de Velasco, A.M., Niessen, C.M., Borradori, L., Kuikman, I., Hulsman, E.H.M., Fässler, R., Owaribe, K., and Sonnenberg, A. The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta4 subunit. J. Cell Sci. 110: 169-178 (1997).

Borradori, L., Koch, P.J., Niessen, C.M., Erkeland, S., van Leusden, M.R., and Sonnenberg, A. The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit. J. Cell Biol. 136: 1333-1347 (1997).

Niessen, C.M., Hulsman, E.H.M., Rots, E.S., Sánchez-Aparicio, P., and Sonnenberg, A. Integrin alpha6beta4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Mol. Biol. Cell 8: 555-566 (1997).

Gimond, C., and Sonnenberg, A. Activation states of integrins. In "Integrin-ligand interaction" (JA Eble and K. Kühn), Landes Bioscience, Austin, Texas, Chapter 5.2, pp 219-240 (1997).

De Melker, A.A., Sterk, L.M.Th., Delwel, G.O., Fles, D.L.A., Daams, H., Weening, J.J., and Sonnenberg, A. The A and B variants of the alpha3 integrin subunit: tissue distribution and functional characterization. Lab. Invest. 76: 547-564 (1997).

Delwel, G.O., Kuikman, I., van der Schors, R.C., de Melker, A.A., and Sonnenberg, A. Identification of the cleavage sites in the alpha6A subunit. Structural requirments for cleavage and functional analysis of the uncleaved alpha6Abeta1 integrins. Biochem. J., 324: 263-272 (1997).

Sterk, L.M.Th., de Melker, A.A., Kramer, D., Kuikman, I., Chand, A., Claessen, N., Weening, J.J., and Sonnenberg, A. Glomerular extracellular matrix components and integrin. Cell Adh. Commun. in press (1997).

Modderman, P.W., Beuling, E.A., Govers, L.A.T., Calafat, J., Janssen, H., von dem Borne, A.E.G.Kr., and Sonnenberg, A. P-selectin tyrosine 777 is part of a signal required for sorting to secretory granules during biosynthesis. Biochem. J., submitted.

Scheffer, H., Stulp, R.P., Verlind, E., van der Meulen, M., Bruckner-Tuderman, L., Gedde-Dahl Jr, T., te Meerman, G.J., Sonnenberg, A, Buys, C.H.C.M., and Jonkman, M.F. Implication of intragenic marker homozygosity and haplotype sharing in a rare autosomal recessive disorder: The example of the collagen type XVII (Col 17A1) locus in generalized atrophic benign epidermolysis bullosa (GABEB). Human Genetics, in press.

Niessen, C.M., Hulsman, E.H.M., Oomen, L.C.J.M., and Sonnenberg, A. A minimal region on beta4 that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J. Cell Science, submitted.

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