Integrin subunits

Beta-1 integrin subunit

Factsheet

Human

Cys-rich domains 4

N-glycos. sites 12

Censerved cysteines 56

Total cysteines 56

Pred. mw from sequence 86,3

Size (non reduced) 120

Size (reduced) 130

Number of aa 778

Number of aa cyto domain 47

Size mRNA 4,2

Chromosome 10

The beta-1 subunit is also known as CD29. This subunit is expressed on cells except erythrocytes. For this integrin subunit, there's a knockout mouse available. Mice lacking this subunit show peri-implantation lethality with inner cell mass (ICM) failure ( Stephens et al., 1995. Genes Dev. 9, 1883-1895 ).

Amino acid sequences.

Beta-1 human HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Beta-1 chick HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Beta-1 mouse HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Beta-1 Xenopus HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Genbank sequences (EMBL) which exist for this integrin subunit

Accession # Description Reference

U27351 Cat beta-1. Complete coding sequence Willett, 1995. Unpuplished

U12309 Rat beta-1 mRNA. Complete coding sequence Malek-Hedayat et al., 1995. Gene 158, 287-290

J03736 Xenopus beta-1 mRNA. Complete coding sequence DeSimone et al., 1988. J. Biol. Chem. 263, 5333-5340

X07979 Human beta-1A Argraves et al., 1987. J. Cell Biol. 105, 1183-1190

M84237 Human beta-1C Languino et al., 1992. J. Biol. Chem. 267, 7116-7120

U28252 Human beta-1D mRNA. Cytoplasmic domain. Partial coding sequence van der Flier et al., 1995. FEBS Lett. 369, 340-344

Antibody's against beta-1 subunit

Name Against Species Type Reference Com.

TS2/16 Beta-1(human) Mouse Mono Hemler et al., 1984. J. Immunol. 132, 3011-3018

1A5 Beta-1 (human) Mouse Mono Hemler et al., 1984. J. Immunol. 132, 3011-3018

AIIB2 Beta-1 (human) Rat Mono Werb et al., 1989. J. Cell. Biol. 109, 877-889

K20 Beta-1 (human) Mouse Mono Amiot et al., 1986. Scand. J. Immunol. 23, 109-118

MB 1.2 Beta-1 Rat Mono Hieda et al., 1992. J. Cell. Biol. 116, 1497-1506

Beta-1 polycl Beta-1 c Rabbit Poly Tarone

Polycl beta-1 Beta-1 (mouse) Rabbit Poly Bernardi

7E2 Beta-1 (hamster) Mouse Mono Brown and Juliano, 1988. Exp. Cell. Res. 177, 303-318

P4G11 Beta-1 (human) Mouse Mono J. Cell. Biol. 121, 1141-1152 Yes

P5D2 Beta-1 (human) Mouse Mono J. Cell. Biol. 121, 1141-1152

V2E9 Beta-1 (chicken) Mouse Mono J. Cell. Biol. 110, 175-184

CSAT Beta-1 (chicken) Mouse Mono J. Cell. Biol. 95, 654-666

8C8 Beta-1 (Xe) Mouse Mono Development. 115, 595-605

JB1 Beta-1 (Hu) Mouse Mono Reference Yes

JB1a (J10) Beta-1 (Hu) Mouse Mono Reference Yes

DF5 Beta-1 (Hu) Mouse Mono Reference Yes

LM534 Beta-1 (Hu/Hmst/Rb) Mouse Mono Reference Yes

353 Beta-1 (hu) Mouse Mono Reference Yes

JB1B Beta-1 (hu) Mouse Mono Reference Yes

B44 Beta-1 (hu) Mouse Mono Reference Yes

12G10 Beta-1 (hu) Mouse Mono Reference Yes

BE3 Beta-1 (hu) Mouse Mono Reference Yes

Ha2/5 Beta-1 (rt) Hamster Mono Reference Yes

HMbeta1-1 Beta-1 (rt) Hamster Mono Reference Yes

Last updated on 03/10/97
© 1997 jkoster@hotmail.com

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	Human
Cys-rich domains	4
N-glycos. sites	12
Censerved cysteines	56
Total cysteines	56
Pred. mw from sequence	86,3
Size (non reduced)	120
Size (reduced)	130
Number of aa	778
Number of aa cyto domain	47
Size mRNA	4,2
Chromosome	10

Beta-1 human	HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
Beta-1 chick	HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
Beta-1 mouse	HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
Beta-1 Xenopus	HDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK

Accession #	Description	Reference
U27351	Cat beta-1. Complete coding sequence	Willett, 1995. Unpuplished
U12309	Rat beta-1 mRNA. Complete coding sequence	Malek-Hedayat et al., 1995. Gene 158, 287-290
J03736	Xenopus beta-1 mRNA. Complete coding sequence	DeSimone et al., 1988. J. Biol. Chem. 263, 5333-5340
X07979	Human beta-1A	Argraves et al., 1987. J. Cell Biol. 105, 1183-1190
M84237	Human beta-1C	Languino et al., 1992. J. Biol. Chem. 267, 7116-7120
U28252	Human beta-1D mRNA. Cytoplasmic domain. Partial coding sequence	van der Flier et al., 1995. FEBS Lett. 369, 340-344

Name	Against	Species	Type	Reference	Com.
TS2/16	Beta-1(human)	Mouse	Mono	Hemler et al., 1984. J. Immunol. 132, 3011-3018
1A5	Beta-1 (human)	Mouse	Mono	Hemler et al., 1984. J. Immunol. 132, 3011-3018
AIIB2	Beta-1 (human)	Rat	Mono	Werb et al., 1989. J. Cell. Biol. 109, 877-889
K20	Beta-1 (human)	Mouse	Mono	Amiot et al., 1986. Scand. J. Immunol. 23, 109-118
MB 1.2	Beta-1	Rat	Mono	Hieda et al., 1992. J. Cell. Biol. 116, 1497-1506
Beta-1 polycl	Beta-1 c	Rabbit	Poly	Tarone
Polycl beta-1	Beta-1 (mouse)	Rabbit	Poly	Bernardi
7E2	Beta-1 (hamster)	Mouse	Mono	Brown and Juliano, 1988. Exp. Cell. Res. 177, 303-318
P4G11	Beta-1 (human)	Mouse	Mono	J. Cell. Biol. 121, 1141-1152	Yes
P5D2	Beta-1 (human)	Mouse	Mono	J. Cell. Biol. 121, 1141-1152
V2E9	Beta-1 (chicken)	Mouse	Mono	J. Cell. Biol. 110, 175-184
CSAT	Beta-1 (chicken)	Mouse	Mono	J. Cell. Biol. 95, 654-666
8C8	Beta-1 (Xe)	Mouse	Mono	Development. 115, 595-605
JB1	Beta-1 (Hu)	Mouse	Mono	Reference	Yes
JB1a (J10)	Beta-1 (Hu)	Mouse	Mono	Reference	Yes
DF5	Beta-1 (Hu)	Mouse	Mono	Reference	Yes
LM534	Beta-1 (Hu/Hmst/Rb)	Mouse	Mono	Reference	Yes
353	Beta-1 (hu)	Mouse	Mono	Reference	Yes
JB1B	Beta-1 (hu)	Mouse	Mono	Reference	Yes
B44	Beta-1 (hu)	Mouse	Mono	Reference	Yes
12G10	Beta-1 (hu)	Mouse	Mono	Reference	Yes
BE3	Beta-1 (hu)	Mouse	Mono	Reference	Yes
Ha2/5	Beta-1 (rt)	Hamster	Mono	Reference	Yes
HMbeta1-1	Beta-1 (rt)	Hamster	Mono	Reference	Yes