If possible, stay clear of high grass or woods during endemic periods (May through September).
Wear clothing that fits snugly or buttons at the wrists, ankles, and waist. Tuck trouser legs into socks, boots, or shoes if possible and make sure your shirt is tucked in.
Search your body often ... very often. Remove as much clothing as is prudently possible to check skin and clothing.
Use insect sprays that contain DEET or permethrin.
In Decmber 1998, the FDAA approved a vaccine against Lyme disease called LYMErix (manufactured by SmithKline Beecham). However, it takes three shots over a full year to build up to its maximum immunity, and even then it isn't 100% protective. It won't eliminate the threat, so the precautions stated above still need to be taken.