Rick & Karen- Supermarket: At anytime in the day, If you are in the part of the town where the grocery shop is, you can see Rick & Karen talking. Rick will ask Karen why she is standing outside and Karen will say that her parents are fightning and that she is embarresed when they kiss and make up. I would avoid this scene by only going to the clinic and grocery store in the early afternoon, atleast before 12, because this probably makes Karen like Rick more.
Rick & Karen- Chicken Farm: After you see Rick and Popuri fight the first time that you walk past the chicken farm, and when Kai comes to the farm and Rick sends him away, you will see Rick and Karen fighting and Karen stomping off.
Rick & Karen- Woods behind Church: In the begining of the game, when you go to the section of the town where the church is, you will see a scene where Karen and Rick talk abot not doing stuff together and go off into the forest together. I would avoid this if you do not want them to like each other more.