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DECODING SCHEME IN THE MOLECULE OF INSULIN (2)
C o d e s 7 and 931 Molecule of insulinChain A Phe,(F), Val(V), Asn(N), Gln(Q), His(H), Leu(L), Cys(C), Gly(G), Ser(S), His(H), Leu(L), Val(V), Glu(E), Ala(A), Leu(L), Tyr(Y), Leu(L), Val(V), Cys(C), Gly(G), Glu(E), Arg(R), Gly(G), Phe(F), Phe(F), Tyr(Y), Thr(T), Pro((P), Lys(K), Ala(A) Chain B Glu(E), Ileu(J), Val(V), Glu(E), Gln(Q), Cys(C), Cys(C), Ala(A), Ser(S), Val(V), Cys(C), Ser(S), Leu(L), Tyr(Y), Gln(Q), Leu(L), Glu(E), Asn(N), Tyr(Y), Cys(C), Asn(N), Number of atoms: Chain A F=23; V=19; N=17, Q=20; H=20; L=22; C=14; G=10; S=14; H=20; L=22; V=19; E=19; A=13; L=22; Y=23; L=22; V=19; C=14; G=10; E=19; R=25; G=10; F=23; F=23; Y=23; T=17; P=17; K=24; A=13; = 556 atoms. Chain B Decoding formula: [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + +S7(X5)] = 931;X1, X2, X3, X4, X5 = Groups of atoms in aminoacids in chain “A” Chain “A” Example 1 X1 = Leu(L), and Cys (C) = =(22 atoms + 14 atoms) = 36 atoms; X2 = Val(V), Cys(C), Gly(G) and Glu(E) = =(19 atoms + 14 atoms + 10 atoms + 19 atoms) = 62 atoms; X3 = Gly(G) = 10 atoms; X4 = Phe(F) = 23 atoms; X5 = Thr(T) = 17 atoms; [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + +S7(X5)] = 931; [ S7(36) + S7(62) + S7(10) + S7(23) + +S7(17)] = 931; S7(X1) = S7(36) = (30+31+32+33+34+35+36) = 231; S7(X2)= S7(62) = (56+57+58+59+60+61+62) = 413; S7(X3) = S7(10) = (4+5+6+7+8+9+10) = 49; S7(X4) = S7(23) = (17+18+19+20+21+22+23) = 140; S7(X5) = S7(17) = (11+12+13+14+15+16+17) = 98; (231 + 413 + 49 + 140 + 98) = 931; ………… Example 2 X1 = Leu(L), and Cys (C) =(22 atoms + 14 atoms) = 36 atoms; X2 = Val(V) and Cys(C) =(19 atoms + 14 atoms ) = 33 atoms; X3 = Gly(G) = 10 atoms; X4 = Arg(R) and Gly(G) = (25 atoms + 10 atoms) = 35 atoms; X5 = Thr(T), and Pro(P) = (17 atoms + 17 atoms) = 34 atoms; [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + S7(X5)] = 931; [ S7(36) + S7(33) + S7(10) + S7(35) + +S7(34)] = 931; S7(X1) = S7(36) = (30+31+32+33+34+35+36) = 231; S7(X2)= S7(33) = (27+28+29+30+31+32+33) = 210; S7(X3) = S7(10) = (4+5+6+7+8+9+10) = 49; S7(X4) = S7(35) = (29+30+31+32+33+34+35) = 224; S7(X5) = S7(34) = (28+29+30+31+32+33+34) = 217; (231 + 210 + 49 + 224 + 217) = 931; ……… Example 3 X1 = His(H), and Leu (L) =(20 atoms + 22 atoms) = 42 atoms; X2 = Leu(L) , Val(V) and Glu(E) =(22 atoms + 19 atoms + 19 atoms ) = 60 atoms; X3 = Tyr(Y) = 23 atoms; X4 = Gly(G) = 10 atoms; X5 = Ala(A) = 13 atoms; S7(X1) + S7(X2) + S7(X3) + S7(X4) + +S7(X5)] = 931;[ S7(42) + S7(60) + S7(23) + S7(10) + +S7(13)] = 931; S7(X1) = S7(42) = (36+37+38+39+40+41+42) = 273; S7(X2)= S7(60) = (54+55+56+57+58+59+60) = 399; S7(X3) = S7(23) = (17+18+19+20+21+22+23) = 140; S7(X4) = S7(10) = (4+5+6+7+8+9+10) = 49; S7(X5) = S7(13) = (7+8+9+10+11+12+13) = 70; (273 + 399 + 140 + 49 + 70) = 931; ……… Example 4 X1 = Leu(L), and Cys (C) =(22 atoms + 14 atoms) = 36 atoms; X2 = Arg(R) = 25 atoms; X3 = Gly(G) = 10 atoms; X4 = Tyr(Y) = 23 atoms; X5 = Pro(P), Lys(K) and Ala(A) = (17 atoms + 24 atoms + 13 atoms) = 54 atoms; [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + +S7(X5)] = 931;[ S7(36) + S7(25) + S7(10) + S7(23) + +S7(54)] = 931;S7(X1) = S7(36) = (30+31+32+33+34+35+36) = 231; S7(X2)= S7(25) = (19+20+21+22+23+24+25) = 154; S7(X3) = S7(10) = (4+5+6+7+8+9+10) = 49; S7(X4) = S7(23) = (17+18+19+20+21+22+23) = 140; S7(X5) = S7(54) = (49+50+51+52+53+54) = 357; (231 + 154 + 49 + 140 + 357) = 931; ……… Chain “B” Example 1 X1 = Glu(E), Ileu(I), Val(V)=(19 atoms + 22 atoms + +19 atoms) = 60 atoms; X2 = Glu(E) and Gln(Q) = ( 19 atoms + 20 atoms) = 39 atoms; X3 = Cys(C) = 14 atoms; X4 = Ala(A) = 13 atoms; X5 = Leu(L) = 22 atoms; [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + +S7(X5)] = 931; [ S7(60) + S7(39) + S7(14) + S7(13) + S7(22)] = 931; S7(X1) = S7(60) = (54+55+56+57+58+59+60) = 399; S7(X2)= S7(39) = (33+34+35+36+37+38+39) = 252; S7(X3) = S7(14) = (8+9+10+11+12+13+14) = 77; S7(X4) = S7(13) = (7+8+9+10+11+12+13) = 70; S7(X5) = S7(22) = (16+17+18+19+20+21+22) = 133; (399 + 252 + 77 + 70 + 133) = 931; ………… Example 2 X1 = Glu(E), Ileu(I), Val(V) and Glu(E) = (19 atoms + +22 atoms + 19 atoms + 19 atoms) = 79 atoms; X2 = Cys(C) and Cys(C) = ( 14 atoms + 14 atoms) = 28 atoms; X3 = Ala(A) = 13 atoms; X4 = Cys(C) = 14 atoms; X5 = Ser(S) = 14 atoms; [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + S7(X5)] = 931; [ S7(79) + S7(28) + S7(13) + S7(14) + S7(14)] = 931; S7(X1) = S7(79) = (73+74+75+76+77+78+79) = 532; S7(X2)= S7(28) = (22+23+24+25+26+27+28) = 175; S7(X3) = S7(13) = (7+8+9+10+11+12+13) = 70; S7(X4) = S7(14) = (8+9+10+11+12+13+14) = 77; S7(X5) = S7(14) = (8+9+10+11+12+13+14) = 77; (532 + 175 + 70 + 77 + 77) = 931; ………… Example 3 X1 = Val(V) , Glu(E) , Gln(Q) and Cys(C)= (19 atoms + 19 atoms + 20 atoms + 14 atoms) = 72 atoms; X2 = Cys(C) = 14 atoms; X3 = Leu(L) = 22 atoms; X4 = Asn(N) = 17 atoms; X5= Tyr(Y) = 23 atoms; [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + S7(X5)] = 931;[ S7(72) + S7(14) + S7(22) + S7(17) + S7(23)] = 931; S7(X1) = S7(72) = (66+67+68+69+70+71+72) = 483; S7(X2) = S7(14) = (8+9+10+11+12+13+14) = 77; S7(X3) = S7(22) = (16+17+18+19+20+21+22) = 133; S7(X4) = S7(17) = (11+12+13+14+15+16+17) = 98; S7(X5) = S7(23) = (17+18+19+20+21+22+23) = 140; (483 + 77 + 133 + 98 + 140) = 931; ………… Example 4 X1 = Ileu(I), and Val (V) =(22 atoms + 19 atoms) = 41 atoms; X2 = Gln(Q) and Cys(C) =(20 atoms + 14 atoms ) = 34 atoms; X3 = Ala(A) = 13 atoms; X4 = Gln(Q) = 20 atoms; X5 = Asn(N) and Tyr(Y) = (17 atoms + 23 atoms) = 40 atoms; [ S7(X1) + S7(X2) + S7(X3) + S7(X4) + S7(X5)] = 931; [ S7(41) + S7(34) + S7(13) + S7(20) + S7(40)] = 931; S7(X1) = S7(41) = (35+36+37+38+39+40+41) = 266; S7(X2)= S7(34) = (28+29+30+31+32+33+34) = 217; S7(X3) = S7(13) = (7+8+9+10+11+12+13) = 70; S7(X4) = S7(20) = (14+15+16+17+18+19+20) = 119; S7(X5) = S7(40) = (34+35+36+37+38+39+40) = 259; (266 + 217 + 70 + 119 + 259) = 931; ……… Etc. |
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