N E W 7

DECODING THE MOLECULE

OF INSULIN

Molecule of insulin

Chain A

Phe,(F), Val(V), Asn(N), Gln(Q), His(H), Leu(L), Cys(C),

Gly(G), Ser(S), His(H), Leu(L), Val(V), Glu(E), Ala(A), Leu(L),

Tyr(Y), Leu(L), Val(V), Cys(C), Gly(G), Glu(E), Arg(R), Gly(G),

Phe(F), Phe(F), Tyr(Y), Thr(T), Pro((P), Lys(K), Ala(A)

Chain B

Glu(E), Ileu(J), Val(V), Glu(E), Gln(Q), Cys(C), Cys(C), Ala(A),

Ser(S), Val(V), Cys(C), Ser(S), Leu(L), Tyr(Y), Gln(Q), Leu(L),

Glu(E), Asn(N), Tyr(Y), Cys(C), Asn(N),

Number of atoms:

Chain A

F=23; V=19; N=17, Q=20; H=20; L=22; C=14; G=10; S=14; H=20;

L=22; V=19; E=19; A=13; L=22; Y=23; L=22; V=19; C=14; G=10;

E=19; R=25; G=10; F=23; F=23; Y=23; T=17; P=17; K=24;

A=13; = 556 atoms.

Chain B

E=19; J=22; V=19; E=19; Q=20; C=14; C=14; A=13; S=14; V=19;C=14;

S=14; L=22; Y=23; Q=20; L=22; E=19; N=17; Y=23; C=14; N= 17;=378 atoms

Triplets of amino acids

Chain "A"

Amino acids		Number of atoms
F,V,N	23		19	19
Q,H,L	20		20	22
C,G,S	14		10	14
H,L,V	20		22	19
E,A,L	19		13	22
Y,L,V	23		22	19
C,G,E	14		10	19
R,G,F	25		10	23
F,Y,T	23		23	17
P,K,A	17		24	13
Sum	198		173	185
Analog code	891		371	581
Total	1089		544	766

Chain "A" = (1089 + 544 + 766) = 2399;

Chain "B"

Amino acids		Number of atoms
E,I,V	19		22	19
E,Q,C	19		20	14
C,A,S	14		13	14
V,C,S	19		14	14
L,Y,Q	22		23	20
L,E,N	22		19	17
Y,C,N	23		14	17
Sum	138		125	115
Analog code	831		521	511
Total	969		646	626

Chain "B" = (969 + 646 + 626) = 2241;

(Chain "A" + Chain "B") = (2399 + 2241) = 4640;

4640 = [ 197 + (931 + 931 + 931 + 931) + 719] ;

Comment:

Input elements = Codes 19, 7 and 931.

Output elements = Triplets of amino acids.

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Last updated: 08/27/01.