PRODUCTION AND REGULATION OF INTERLEUKIN-11 BY BREAST
CANCER CELLS.
Marc Lacroix, Brigitte Siwek, Pierre J. Marie, Jean Jacques
Body
Cancer Letters (1998) 127, 29-35
We have studied the production of interleukin-11 (Il-11) by
thirteen breast cancer cell (BCC) lines (BT-20, BT-483, CAMA-1, Hs578T, IBEP-1, IBEP-2, IBEP-3,
MCF-7, MDA-MB-231, MDA-MB-361, SK-Br-3, T-47D, and ZR-75-B). Two of these cell lines (MDA-MB-231
and Hs578T) expressed the cytokine, at both the protein and mRNA levels. Il-11
did not modulate the growth of five BCC lines examined, including the two
cytokine-producing ones. The production of Il-11 was increased by
transforming growth factor-ß1 in a dose-dependent manner with a rapid (2h) and
transient (24h) mRNA induction, but not by epidermal growth factor, insulin-like
growth factors-I and -II, basic fibroblast growth factor, platelet-derived growth
factor or parathyroid hormone. The cyclic AMP inducer forskolin and the activator
of protein kinase C phorbol 12-myristate 13-acetate also stimulated the production
of Il-11. Besides Il-11, MDA-MB-231 and Hs578T were the only BCC lines to produce
interleukin-6 (Il-6) protein and mRNA. Since Il-11 and Il-6 are potent stimulators
of osteoclast development and bone is a major source of TGF-ß1, our data suggest
that Il-11, together with Il-6, contribute to the high bone destructive capacity
of MDA-MB-231 cells and could play a role in breast cancer-induced osteolysis.
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To obtain additional information on the IBEP-1, IBEP-2, and IBEP-3 breast cancer cell lines, see these two papers:
ESTABLISHMENT AND CHARACTERIZATION OF THREE NEW BREAST-CANCER CELL LINES (1998).
PROTEIN PRODUCTION BY OSTEOBLASTIC CELLS: MODULATION BY BREAST CANCER CELL-DERIVED FACTORS (2000).
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To obtain additional information on the other breast cancer cell lines, please consult the following paper:
RELEVANCE OF BREAST CANCER CELL LINES AS MODELS FOR BREAST TUMOURS: AN UPDATE (2004).
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To obtain additional information on interleukin-11 production by breast cancer cells, see these two papers:
THE ASPIRIN METABOLITE SALICYLATE INHIBITS BREAST CANCER CELLS GROWTH AND THEIR SYNTHESIS OF THE OSTEOLYTIC CYTOKINES INTERLEUKINS-6 AND -11 (1999).
INTERLEUKINS-6 AND -11 EXPRESSION IN PRIMARY BREAST CANCER AND SUBSEQUENT DEVELOPMENT OF BONE METASTASES (2001).
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