SIGNIFICANCE, DETECTION AND MARKERS OF DISSEMINATED BREAST CANCER CELLS.
Marc Lacroix
Endocrine-Related Cancer (2006) 13, 1033-1067
The development of distant metastases is the major cause of death from breast cancer. In order to
predict and prevent tumour spreading, many attempts are being made to detect small numbers of tumour cells that have shed from the
primary lesions and have moved to lymph nodes, blood or bone marrow. This article presents the advantages and limitations of techniques
used for disseminated tumour cells (DTC) detection. DTC markers are listed and the most currently used of them (KRT19, CEACAM5,
TACSTD1, MUC1, EGFR, ERBB2, SCGB2A2, SCGB2A1, SCGB1D2, PIP, SBEM, TFF1, TFF3, ANKRD30A, SPDEF, ESR1, SERPINB5, and GABRP) are discussed,
notably on the basis of recent data on breast tumour portraits ("luminal epithelial-like", "basal/myoepithelial-like" and "ERBB2").
The significance of DTC for prognosis and prediction of response to therapy is examined. DTC viability, the notion of cell dormancy and
the concept of breast cancer stem cells are also discussed.
Summary
Dissemination sites: lymph nodes, peripheral blood, bone marrow
Variability of results in DTC analysis
Techniques for DTC detection
Markers for DTC detection
Markers with low breast (cancer) specificity
Markers with high breast (cancer) specificity
Genetics and phenotype of DTC, as compared to primary tumours
Recent data on breast cancer classification and progression
Genetic alterations in DTC
Significance of DTC in LN, PB, and BM
Prognosis and correlations
Monitoring the response to therapy – Predictive potential of DTC
A new concept: breast cancer stem cells
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Affiliations:
Laboratoire Jean-Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet - Université Libre de Bruxelles (ULB), Bruxelles
(Brussels), Belgique (Belgium)
InTextoResearch, 4 chemin de Hoevel, 4837 Baelen, Belgique (Belgium)
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