RELEVANCE OF BREAST CANCER CELL LINES AS MODELS FOR BREAST TUMOURS: AN UPDATE.STABLE PORTRAIT OF BREAST TUMORS DURING PROGRESSION. DATA FROM BIOLOGY, PATHOLOGY, AND GENETICS.
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ABOUT GATA3, HNF3A AND XBP1, THREE GENES CO-EXPRESSED WITH THE OESTROGEN RECEPTOR-ALPHA GENE (ESR1) IN BREAST CANCER.


Marc Lacroix, Guy Leclercq
Molecular and Cellular Endocrinology (2004) 219, 1-7

   In breast tumours and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the oestrogen receptor-alpha (ER-alpha) gene, ESR1. Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors. Here we present these factors and we discuss their potential involvement in the ER-alpha-mediated actions in BCC. We notably show the relations that exist, or might exist, between these factors and the oestrogen-inducible trefoil factor pS2 (gene TFF1).



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