Nerve pain
These are discussed in detail elsewhere. nerve pain Exercise arthritis. (see Rheumatoid Arthritis and ACR Highlights) An initial trial with a soluble IL-1 receptor did not show efficacy but is likely to have targeted the wrong IL-1 receptor; studies are in progress currently with a recombinant form of the endogenous IL-1 receptor antagonist. It should be noted that corticosteroids inhibit production of many cytokines (e. g. nerve pain Arthritis of the eye. , IL-1, TNF, IL-6 and IL-8), of prostanoids, and of proteolytic enzymes. However, these beneficial effects of steroids are counterbalanced by a number of undesirable side effects that limit the usefulness of corticosteroids in this disease such as weight gain, hypertension, osteoporosis, and ischemic necrosis of bone. (top of section) Targeting distal events Nonsteroidal anti-inflammatory agents exert their anti-inflammatory effects by inhibiting synthesis of prostanoids via cyclooxygenase (COX) inhibition. nerve pain Exercise arthritis. New classes of NSAIDs are being developed that specifically inhibit COX-2 (rather than both COX-1 and -2), and these are likely to be considerably safer than conventional agents. (more info on Cox-2) Inhibitors of metalloprotease enzymes, and kinin and substance P receptor antagonists, are also in development and/or clinical trial. (top of section) Future - gene therapy? Therapeutic proteins can be introduced and "overexpressed" in rabbit synovia via viral or nonviral gene transfer vectors. Transduction of synovial cells and chondrocytes with the IL-1 receptor antagonist gene has been successfully accomplished in vitro and in vivo in animal studies, but beneficial results are short-lived. The feasibility of this approach in humans is currently being evaluated.
Nerve pain
Herb || Arthritis of the hand || Exercise arthritis || Chronic pain medications