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Adams & Samuel A. bodybuilding videos Buy legal steroids. McCueDepartment of Physiology and Biophysics, University of California, Irvine, Ca. Source: Journal of Applied Physiology 84(5): 1716-1722, 1998Summary: The present study was undertaken to test the hypothesis that direct IGF-I infusion would result in an increase in muscle DNA as well as in various measurements of muscle size. Either 0. bodybuilding videos Steroid weight gain. 9% saline or nonsystemic doses of recombinant human IGF-I (rhIGF- 1) were infused directly into a non-weight-bearing muscle of rats, the tibialis anterior (TA), via a fenestrated catheter attached to a subcutaneous miniosmotic pump. Saline infusion had no effect on the mass, protein content, or DNA content of TA muscles. Local IGF-I infusion had no effect on body or heart weight. bodybuilding videos Steroid rash. The absolute weight of the infused TA muscles was ~9% greater (P < 0. 05) than that of the contra-lateral TA muscles. IGF-I infusion resulted in significant increases in the total protein and DNA content of TA muscles (P < 0. 05). As a result of these coordinated changes, the DNA-to-protein ratio of the hypertrophied TA was similar to that of the contra-lateral muscles. These results suggest that IGF-I may be acting to directly stimulate processes such as protein synthesis and satellite cell proliferation, which result in skeletal muscle hypertrophy. Discussion: The details of the mechanisms and pathways by which mechanical stress stimulates localized muscle fiber hypertrophy are still being elucidated. It is clear however, that growth hormone (GH), fibroblast growth factors (FGF) and insulin-like growth factors (IGF) play a central role in this process. Insulin-like growth factor I (IGF-I) peptide levels have been shown to increase in overloaded skeletal muscles (G. R. Adams and F.
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