Anabolic steroid cycle
244(1):1-4, 1998Summary:An in vitro study was performed to assess the ability of non-steroidal compounds to bind with the androgen receptor (AR) and activate transcription. anabolic steroid cycle Anabolic steroid cycle. The compounds to be tested were derived from the structure of the anti-androgen R-Bicalutamide. The androgen receptors were prepared using the prostate glands of male Sprague-Dawley rats. Transcriptional activation was measured using transfected CV-1 cells. anabolic steroid cycle Facts about steroids. In order to assess the binding affinity of these compounds, they were incubated in a medium containing androgen receptors. Each compound was tested in increasing concentrations until the minimum concentration that resulted in maximum receptor saturation was attained. Then the experiment was repeated using the high affinity ligand, 3H-MIB. anabolic steroid cycle Steroid use in high school athletes. The concentration of each compound needed to completely saturate the androgen receptors was then compared to the amount of 3H-MIB needed to do the same. The efficacy (i. e. maximal degree of AR-mediated transcriptional activity observed) and potency (i. e. the lowest concentration of ligand able to induce maximal transcriptional activity) were determined by comparing the transcriptional activity induced by various concentrations of each compound to that of dihydrotestosterone (DHT). The efficacy of individual compounds compared to DHT was calculated by dividing the maximal transcriptional activation observed for each compound by the maximal transcriptional activation observed for DHT. All experiments were performed in triplicate. Potency was reported as the lowest concentration of the ligand used during transfection experiments capable of producing maximal androgen receptor-mediated transcriptional activity. Discussion:First a few words about the study design.
Anabolic steroid cycle
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