Benign Myalgic EncephalomyelitisME InternationalMyalgic EncephalomyelitisME International

Chronic Fatigue Syndrome: A Working Case Definition

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Case Definition for The Chronic Fatigue Syndrome

Acknowledgments: The authors thank Mrs. Josephine M. Lister for manuscript preparation.

Requests for reprints should be addressed to Gary P. Holmes, M.D.; Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control; Atlanta, GA 30333.

References

1. Tow M, Morag A, Ravid Z, et al. Prolonged atypical illness associated with serological evidence of persistent Epstein-Barr virus infection. Lancet. 1982; 1:61-4.

2. Dubois RE, Seeley JK, Brus I, et al. Chronic mononucleosis syndrome. South Med J. 1984; 77:1376-82.

3. Jones JF, RAY CG, Minnich LL, et al. Evidence for active Epstein-Barr virus infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies. Ann Intern Med. 1985; 102:1-7.

4. Straus SE, Tosato G, Armstrong G, et al. Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Ann Intern Med. 1985; 102:7-16.

5. Merlin TL. Chronic mononucleosis: pitfalls in the laboratory diagnosis. Hum Pathol. 1986; 17:2-8.

6. Holmes GP, Kaplan JE, Stewart JA, Hunt B, Pinskey PF, Schonberger LB. A cluster of patients with a chronic mononucleosis-like syndrome: is Epstein-Barr virus the cause? JAMA. 1987; 257:2297-2302.

7. Buchwald D, Sullivan JL, Komaroff AL. Frequency of "chronic active Epstein-Barr virus infection" in a general medical practice. JAMA. 1987; 257:2303-7.