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Urinary tract infection - chronic or recurrent

Definition

Chronic urinary tract infection is a disorder involving repeated or prolonged bacterial infection of the bladder or lower urinary tract (urethra).

Causes, incidence, and risk factors

Most urinary tract infections (UTI or cystitis) occur in the lower urinary tract, which includes the bladder and urethra. Cystitis is caused when the normally sterile lower urinary tract is infected by bacteria and becomes inflamed. Cystitis is very common.

Most of the time, symptoms of cystitis disappear within 24 - 48 hours after treatment begins. Chronic or recurrent urinary tract infection includes repeated episodes of cystitis (more than 2 in 6 months), or urinary tract infection that does not respond to the usual treatment or that lasts longer than 2 weeks.

In young girls, recurrent urinary tract infections may be an indication of a urinary tract abnormality (such as vesicoureteral reflux), and should be evaluated by a medical care provider. In boys, even a single urinary tract infection should be evaluated, because urinary tract infections in boys are extremely uncommon in the absence of urinary tract abnormalities.

The elderly population are at increased risk for developing cystitis due to incomplete emptying of the bladder associated with such conditions as benign prostatic hyperplasia (BPH), prostatitis, and urethral strictures.

Also, lack of enough fluids, bowel incontinence, immobility or decreased mobility, having a Foley catheter, and placement in a nursing home, all put a person at increased risk for developing cystitis.

Symptoms

Additional symptoms that may be associated with this disease:

  • Nausea and vomiting
  • Fever
  • Fatigue
  • Fever
  • Chills
  • Mental changes or confusion. (In elderly people, mental changes or confusion often are the only signs of a possible urinary tract infection.)

Signs and tests

Chronic or recurrent urinary tract infection means one of the following is true:

  • Symptoms return 2 or more times in 6 months
  • Symptoms of a single episode last longer than 2 weeks
  • Symptoms last longer than 48 hours after treatment has begun

Tests that may be done include:

  • A urinalysis -- commonly reveals white blood cells (WBC) or red blood cells (RBC).
  • A urine culture (clean catch) or catheterized urine specimen -- may reveal bacteria in the urine. A urine culture that is positive for more than 2 weeks even with treatment indicates chronic or recurrent UTI.
  • An abdominal ultrasound or KUB (abdominal x-ray) -- may be needed to evaluate the status of the renal system (kidneys, ureters, and bladder).

Treatment

Mild cases of acute cystitis may disappear on their own without treatment. However, because of the risk of the infection spreading to the kidneys (complicated UTI), treatment is usually recommended. Also, due to the high death rate in the elderly, prompt treatment is recommended.

MEDICATIONS

Antibiotics may be used to control the bacterial infection. You MUST finish the entire course of prescribed antibiotics. Commonly used antibiotics include:

  • Nitrofurantoin
  • Sulfa drugs (sulfonamides)
  • Amoxicillin
  • Cephalosporins
  • Trimethoprim-sulfamethoxazole
  • Doxycycline
  • Fluoroquinolones

Chronic or recurrent urinary tract infection should be treated thoroughly because of the chance of kidney infection (pyelonephritis). Antibiotics control the bacterial infection. They may need to be given for long periods of time (as long as 6 months to 2 years), or stronger antibiotics may be needed. As an additional precaution, low-dose antibiotics may be recommended after acute symptoms have subsided.

Phenazopyridine hydrochloride (pyridium) may be used to reduce the burning and urgency associated with cystitis. In addition, ascorbic acid may be recommended to decrease the concentration of bacteria in the urine.

SURGERY

Surgery is generally not needed to treat urinary tract infections.

OTHER THERAPY

Preventive measures may reduce symptoms and prevent recurrence of infection. If you keep the genital area clean and wipe from front to back, you may prevent dragging bacteria from the rectal area to the urethra.

Urinating immediately after sexual intercourse may help eliminate any bacteria that may have been introduced during intercourse. Not urinating for a long period of time may allow bacteria time to multiply. Frequent urination may reduce the risk of cystitis in those who are prone to urinary tract infections.

DIET

Increasing the intake of fluids (2000 - 4000 cc per day) encourages frequent urination that flushes the bacteria from the bladder. Avoid fluids that irritate the bladder, such as alcohol, citrus juices, and drinks containing caffeine.

MONITORING

Follow-up urine cultures may be needed to make sure that bacteria are no longer present in the bladder.

Expectations (prognosis)

Most cases are cured without complication after adequate treatment. The treatment may be prolonged.

Complications

  • Pyelonephritis
  • Kidney abscess
  • Swelling of the kidneys (hydronephrosis)

Calling your health care provider

Call for an appointment with your health care provider if symptoms of cystitis persist after treatment, or recur more than 2 times in 6 months.

Call your health care provider if symptoms worsen or new symptoms develop, especially persistent fever, back pain or flank pain, and vomiting.

Prevention

Keeping your genital area clean may reduce the chances of introducing bacteria through the urethra. Wipe the genital area from front to back to reduce the chance of "dragging" bacteria from the rectal area to the urethra.

Increasing your intake of fluids may allow urination to flush out the bacteria from the bladder.

Refraining from urinating for long periods of time can give bacteria time to multiply. If you are prone to urinary tract infections, urinate frequently to reduce the risk of developing cystitis.

Long-term use of prophylactic (preventative) antibiotics may be recommended for some people who are prone to chronic or recurrent urinary tract infections.

Illustrations

Female urinary tract
Female urinary tract
Male urinary tract
Male urinary tract
Voiding cystourethrogram
Voiding cystourethrogram
Vesicoureteral reflux
Vesicoureteral reflux

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UTI - chronic or recurrent