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Kidney infection (pyelonephritis)Definition Pyelonephritis is an infection of the kidney and the ducts that carry urine away from the kidney (ureters). Causes, incidence, and risk factors Pyelonephritis most often occurs as a result of urinary tract infection, particularly in the presence of occasional or persistent backflow of urine from the bladder into the ureters or kidney pelvis (vesicoureteric reflux). Pyelonephritis can be further classified as follows:
Although cystitis (bladder infection) is common, pyelonephritis occurs much less often. The risk is increased if there is a history of cystitis, renal papillary necrosis, kidney stones, vesicoureteric reflux, or obstructive uropathy. The risk is also increased when there is a history of chronic or recurrent urinary tract infection and when the infection is caused by a particularly aggressive type of bacteria. Acute pyelonephritis can be severe in the elderly and in people who are immunosuppressed (for example, those with cancer or AIDS). Symptoms
Signs and tests An examination may show tenderness on palpation (pressing) over the kidney.
Treatment The goals of treatment are control of the infection and reduction of symptoms. Acute symptoms usually resolve within 48 to 72 hours after appropriate treatment. Due to the high mortality rate in the elderly population and the risk of permanent kidney damage, prompt treatment is recommended. After obtaining a urine culture to identify the bacteria, antibiotics are selected to treat the infection. MEDICATIONS Intravenous (IV) antibiotics may be used initially to control the bacterial infection if your infection is severe or you cannot take antibiotics by mouth. In acute cases of pyelonephritis, you may receive a 10- to 14-day course of antibiotics. Chronic pyelonephritis may require long-term antibiotic therapy. It is imperative that you finish taking the entire course of prescribed antibiotics. Commonly used antibiotics include the following:
Kidney damage can result from these infections. The elderly, infants, and people with a compromised immune system are at increased risk for developing sepsis (a severe blood infection). Often, these people will be admitted to the hospital to receive frequent monitoring for potential problems and to receive IV antibiotics, additional IV fluids, and other medications as necessary. MONITORING In diabetic patients and pregnant women, as well as in people with spinal paralysis, follow-up should include a urine culture at the completion of antibiotic therapy to ensure that bacteria are no longer present in the urine. Expectations (prognosis) Most cases of pyelonephritis resolve without complication after the treatment. However, the treatment may need to be aggressive or prolonged. If sepsis occurs, it can be fatal. Complications
Calling your health care provider Call your health care provider if symptoms suggesting pyelonephritis occur. If you have pyelonephritis, call your health care provider if new symptoms develop, especially decreased urine output, persistent high fever, or severe flank pain or back pain. Prevention Prompt and complete treatment of cystitis (bladder infection) may prevent development of many cases of pyelonephritis. Chronic or recurrent urinary tract infection should be treated thoroughly because of the chance of infection of the kidneys. LIFESTYLE CHANGES Preventive measures may reduce symptoms and prevent recurrence of infection. Keeping the genital area clean and remembering to wipe from front to back may reduce the chance of introducing bacteria from the rectal area to the urethra. Urinating immediately after sexual intercourse may help eliminate any bacteria that may have been introduced during intercourse. Refraining from urinating for long period of time may allow bacteria time to multiply, so frequent urination may reduce the risk of cystitis in those who are prone to urinary tract infections. DIET Increasing the intake of fluids (64 to 128 ounces per day) encourages frequent urination that flushes bacteria from the bladder. Drinking cranberry juice prevents certain types of bacteria from attaching to the wall of the bladder and may lessen the chance of infection. Illustrations
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