The Psi Plague campaign world starts in the year 2045. It is a very different world than our current world. About 60% of the human race succumbed to an unknown viral plague, or it's side effects, in the years following 2005. Technology is both more advanced and also less advanced than it is today. The United States and many other large countries have broken apart into a much larger number of regional groups.
This is a 3rd Generation setting. The player characters are presumed to be between 15 and 35 years old. They are the 3rd generation that has lived with psionic powers.
The source of the Plague is unknown and is left to GM discretion. What is known is the mortality rate and side effects among some of the survivors. There are a number of easy options for a source of the virus. The virus could have been the result of bio-warfare experiments, whether a nation-state such as Iraq or terrorist group such as al Queda. The Psi World modules The Hammer Shall Strike and Underground Railroad take place in a world where the plague is thought to have come from the Mars exploration program. It could have come from the Vorlons such as in the Babylon 5 universe. The virus could have been a poorly designed bug that was supposed to kill all the humans such as in Apocalypse Troll.
The Great Plague started in 2005. It raged around the world for over four years. Even at this date, forty years later, there are still individuals and small communities that have outbreaks. Approximately 60% of the worlds population died from the Plague or from the social collapse associated with it.
Additional pieces of information:
The following are adventures that are suitable for this setting.