Bad side effects of steroids
The latter action is seen when androdiol is converted to testosterone by this enzyme. bad side effects of steroids Anabolic steroid cycle. The former is seen when DHT is converted to androstanediol (not androstenediol) in muscle tissue (Figure 4): this is the reason DHT is not an effective anabolic in muscle tissue. ) Proviron also undergoes this transformation and is deactivated in muscle tissue (Figure 5). The conversion of DHT to androstanediol also occurs in scalp tissue, and androstanediol may be of relevance in the development of male pattern baldness. bad side effects of steroids Injection-steroids. Because the enzyme works in two directions, it cannot convert a keto steroid entirely to the hydroxy, or vice versa, because some of what is converted will then be acted upon again and return to its original state. Thus, there will always be a mixture of the two compounds. In some cases, the mixture might favor one side of the balance. bad side effects of steroids Anabolic-steroid-side-effects. 3bHSD is widely distributed in the body. 17beta-hydroxysteroid dehydrogenase (17bHSD)Again, this is an enzyme that can work in two directions. It can convert a steroid that has a keto group in the 17 position (Figure 6, molecule on left) to one that has a hydroxy group in the same position (Figure 6, molecule on right), or vice versa. The former conversion takes place in the case of androstenedione being converted to testosterone. AromataseThis enzyme removes the 19 methyl from AAS and aromatizes the A ring (Figure 7). This means that three, alternating double bonds are formed in that ring. Any process which produces such a pattern of bonds is called aromatization, and the enzyme is called aromatase because it accomplishes this. It is worth noting that aromatization does not require aromatase in some cases: for example, in the case of nandrolone. However, in those AAS which have a 19 methyl, the aromatase enzyme is required for aromatization, since a double bond cannot be formed at carbon 10 unless the 19 methyl is removed. (A carbon atom can have only four bonds, and there would be five in such a case. )Aromatase is the first enzyme we have discussed where we are interested in reducing its activity. This may be done by either of two types (usually) of inhibitors: competitive inhibitors and mechanism-based (suicide) inhibitors. Competitive inhibitors act by binding to the same site of the enzyme as the steroid molecule would. Arimidex, for example, does this. Whatever percentage of enzyme has the inhibitor bound to it, is inactive for as long as the inhibitor is bound. Thus, a small amount of inhibitor might inhibit only a small percentage of the enzyme molecules, whereas a larger amount would inhibit a higher percentage. The inhibitor also must compete with the steroid for access to the binding site. Thus, if there is a very high amount of steroid, the steroid will be likely to "get there first" and the inhibitor will be less effective: unless its concentration is likewise increased.
Bad side effects of steroids
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