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A picture = CO2 transport in RBC :

H₂O + CO₂ ---> C-Anhydrase ---> H₂CO₃ then dissociates
HCO₃^- into blood plasma going to lungs H⁺ + Hb ----> Hb-H to lungs

Oxygen from lungs to cell; ( in ).
Hb-O₂  H⁺ ---> O₂ into cell   Hb-H

O₂ then diffuses into cell tissue. Hb-H is the blood, RBC, returning to lungs.

Acid / Base factor . . . Causes Oxygen to release from RBC into cell where most needed.

What are Buffers ? a picture . . . it is still a complex subject

pH and Buffers

Know what ? DPG Helps unload Oxygen.

Gas exchange at lungs :

out:
HCO₃^-   Hb-H --- > CO₂   OH ^- + H⁺ --- > H₂O and CO₂ exhaled

in:
Hb^- + O₂ inhaled = Hb-O₂ oxygen on way to cell.

Oxygen Trans Diagram

Diffusion to start process

Goto page 3

Again CO₂ enters the blood stream and travels mostly as HCO₃ and the process reverses
at the lungs to expell that CO₂.