| Birth Name: | Dr. Nathaniel Essex | |
| Aliases: | Mr Sinister | |
| Height: | 6'5" | |
| Weight: | 285lbs (129.3 kgs) | |
| Hair: | Black | |
| Eyes: | Red | |
| Powers: | Immortality |
Nathaniel Essex was a biologist in Victorian England who developed advanced theories on human evolution. A geneticist of unparalleled genius, he foresaw the coming mutations that would transform mankind. However, his unorthodox experiments resulted in his banning from the Royal Society and caused his wife to shun him. These rejections led him to ally himself with Apocalypse, an immortal mutant who has witnessed virtually the whole of human history. Apocalypse transformed Essex into the ageless being known as Mr. Sinister.
Sinister plotted the course of certain gene pools for more than a century, discovering that the combination of Scott Summer's and Jean Grey's traits would produce a mutant of incredible power. The future Cyclops was brought to Sinister's orphanage in Nebraska, and the geneticist collected a blood sample from the girl who would come to be known as Phoenix to confirm his findings. Sinister used that sample when Jean died to create a clone, Madelyne Pryor, who later became the evil Goblin Queen.
Nothing really has been heard from Mr Sinister since.
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