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It is a well known fact that many of the enzymes in the liver and other organs can be increased or decreased by treatment with certain drugs and hormones. steroids for sale perscription Steroid chat. This shifting in the enzyme levels can alter the rate of metabolite production of certain intermediate hormones by altering the dynamics of the testosterone-estrogen metabolic pathways - possibly allowing the accumulation (and subsequent tissue excretion) of compounds which under normal circumstances would not accumulate. Increased or reduced activity of one or more of the intracellular enzymes involved in transformation of testosterone to estrogen might lead to intracellular and extracellular accumulation of immediate or remote precursors of those enzymatic reactions. There is, therefore the possibility of a hormonally induced rise in the production of 19-nortestosterone and its metabolites. steroids for sale perscription Steroids for sale perscription. Also it is well known that the end product of a reaction sequence often regulates the activity of other enzymes in a biosynthetic pathway. It is feasible, therefore, that the use of aromatizing anabolic steroids may inhibit one or more of the enzymes involved in the transformation of testosterone (or androstenedione) to estrogen. This end product inhibition may result in product excess (possibly 19-nortestosterone). steroids for sale perscription Steroids for sale perscription. The reduced activity of one of the intracellular enzymes can lead to the intracellular and extracellular accumulation of an immediate or remote precursor somewhere along the metabolic chain. It must still be remembered, however, that there is considerable variation in the metabolites formed from one species to another and from one tissue to another. No one as yet has identified these 19-norsteroids as naturally occurring in the human. The Previous Use of 19-nortestosteroneThe use of exogenous 19-nortestosterone may stimulate the synthesis of certain enzymes and inhibit the synthesis of others so that the end result may be an accumulation and excretion of 19- nortestosterone and its three metabolites as well as the formation of estrogenic compounds. Even after the exogenous 19-nortestosterone is stopped the enzymatic processes may be sufficiently altered so that the athlete may continue to accumulate 19-nortestosterone and therefore continue to show a positive urine test long after the last traces of the exogenous 19- nortestosterone have been excreted. Thus increased enzyme activity forming 19-norsteroids rather than estrogens, might be induced by the exogenous use of 19-nortestosterone. The accumulation and excretion of 19- nortestosterone and its metabolites may further be enhanced by the use of other anabolic steroids as explained above. It's also possible that the use of other drugs such as the anti-estrogens, by similarly affecting the enzymatic pathway of estrogen production, may increase endogenous production and accumulation of 19-nortestosterone. Formation of 19-nortestosterone During the Chromatographic Purification19-norsteroids are easily formed from 19-oxo androstenedione and 19-oxo testosterone in basic methanol (MEOH/OH-). In fact this synthetic method has been used for the formation of 19-norsteroids from 19-oxosteroids11. It also seems logical that the formation of 19-norsteroids could occur during the purification and chromatographic procedures. Increasing the sensitivity of a test would increase the possibility of detecting trace amounts of any steroids formed within the column.
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