Steroid hormones
Eik-Nes in his book "The Androgens of the Testis" has depicted a possible pathway for the production of 17beta-estradiol - this pathway involves several steps including the formation of 19-nortestosterone by the decarboxylation of 19- carboxytestosterone. steroid hormones Steroid facts. Another possible pathway might involve the formation of 19-nortestosterone from androstenedione by way of 19- norandrostenedione. Several years ago it was found that 19- nortestosterone was, contrary to scientific belief, produced endogenously in male horses. Now a ratio is used to detect the exogenous use of 19- nortestosterone in the doping control of racehorses (similar to the ratio used to detect an athlete's use of exogenous testosterone). steroid hormones Effects of anabolic steroids. Dr. Donike has been aware of the possibility of the endogenous production of 19-nortestosterone. To date, however, no evidence has been uncovered to show that 19-nortestosterone is produced endogenously, despite the fact that tens of thousands of urine samples have been analyzed since 1980 using capillary column chromatography coupled with mass spectrometry. steroid hormones Anabolic steroids. There is still the possibility, however, that increasing the sensitivity of a test for a synthetic steroid like 19-nortestosterone, will increase the possibility of detecting trace amounts of the same steroid produced naturally by minor pathways. It is imperative that sizable drug free populations be checked out by any new improvements in techniques. (I have Dr. R. V. Brooks, a chemical endocrinologist at St. Thomas's Hospital Medical School, to thank for some of the above information on 19-nortestosterone. )It is also possible that the use of testosterone and/or other anabolic steroids which aromatize, and/or human chorionic gonadotropin (HCG) may increase the endogenous production of estrogens and therefore possibly the intermediate 19- nortestosterone, thus raising the level of endogenously produced 19-nortestosterone above the detection threshold. For example the use of say Dianabol before a drug tested competition might raise the endogenous level of 19-nortestosterone. Thus the athlete might escape detection of the anabolic steroids he was using (if he stopped them early enough) but may be found positive for 19- nortestosterone - even though he may never have used the 19-nortestosterone. Perhaps the concomitant widespread use of supplements in the sports with the highest incidence of anabolic steroid use (the so called "loaded sports" - powerlifting, weightlifting, bodybuilding and track and field - especially the throwing and sprinting events) may be somehow responsible for increasing endogenous nortestosterone production (possibly as a result of changes in the synthesis, secretion and metabolism of other hormones). Later on in 1986, in Update Three, I wrote:The Endogenous Production of 19-nortestosteroneAs stated in Update Two there are several pathways by which 19-nortestosterone can be formed endogenously in the human body.
Steroid hormones
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