Canadian arthritis society
Therefore, the controlled release drugs like Transdermal fentanyl have the lowest abuse potential. canadian arthritis society Chest wall pain. Oral controlled release opioids like Oxycontin can be crushed to destroy the matrix and they become the equivalent to immediate release forms. (top of page) Side Effects The most common side effect of chronic opioid therapy is constipation secondary to decreased gastrointestinal motility. However, concerns about potential cognitive impairment are more often the reason opioids are not prescribed, particularly in the elderly. canadian arthritis society Arthritis association. However, the available research has not demonstrated deleterious effects on cognition by neuropsychological testing or electroencephalography (EEG) except in patients prescribed multiple types of medications, especially sedatives and hypnotics. Elderly patients are more susceptible to delirium than younger patients. Although no studies have examined this risk of delirium in chronic pain syndromes treated with opioids, post-operative patients are less likely to develop cognitive impairment with fentanyl than morphine. canadian arthritis society Arthritis prevention treatment. A similar study found that cognitive performance was poorer in patients receiving hydromorphone compared to those receiving morphine. (ref 16) Many metabolites of opioids are excreted by the kidney increasing toxicity in the elderly. Creatinine clearance should be monitored to minimize potential toxicity. (top of page) Discontinuation of Opioid Treatment No treatment should be continued without benefit.
Canadian arthritis society
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