U.S. Federal Route 61 is a east-west highway in La Crosse County. It runs from the La Crosse/Vernon County Line, near Coon Valley, to the Minnesota/Wisconsin State Line, near La Crosse. U.S. Rt. 61 passes through the following town in La Crosse County. La Crosse U.S. Rt. 61 is multi-plexed in La Crosse County. U.S. Rt. 14, throughout La Crosse County.
A junction marker on WB WI St Rt 16. WB U.S. Rt. 14/NB U.S. Rt. 61/WB WI St Rt 16 in La Crosse. WB U.S. Rt. 14/NB U.S. Rt. 61/WB WI St Rt 16 on the La Crosse side of the Mississippi River Bridge. (June, 2005) Mid span of the Mississippi River Bridge. WB U.S. Rt. 14/NB U.S. Rt. 61/WB WI St Rt 16 on the westside of the birdge. EB U.S. Rt. 14/SB U.S. Rt. 61/EB WI St Rt 16 near the Minnesota/Wisconsin State Line.