Department of Biological
|Selected Publications||Research Interest|
L., F. Obál, Jr., P. Alföldi, G. Rubicsek, B. Penke, and F.
Obál. Effects of nocturnal intraperitoneal
administration of cholecystokinin in rats: simultaneous increase in sleep,
increase in EEG slow-wave activity, reduction of motor activity, suppression
of eating, and decrease in brain temperature. Brain Res. 438:
Kapás, L., L. Payne, F. Obál, Jr., M. Opp, L. Johannsen, and J. M. Krueger. Sleep in diabetic rats: effects of interleukin 1. Am. J. Physiol. 260: R995-R999, 1991.
Kapás, L., L. Hong, A. Cady, M. R. Opp, A. E. Postlethwaite, J. M. Seyer, and J. M. Krueger. Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factora (TNFa), and TNFa fragments. Am. J. Physiol. 263: R708-R715, 1992.
Kapás, L., M. Shibata, M. Kimura, and J. M. Krueger. Inhibition of nitric oxide synthesis suppresses sleep in rabbits. Am. J. Physiol. 266: R151-R157, 1994.
Kapás, L., F. Obál Jr., A. A. Book, J. B. Schweitzer, R. G. Wiley, and J. M. Krueger. The effects of immunolesion of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep, Brain Res., 712:53-59, 1996.
Kapás, L. and J. M. Krueger. Nitric oxide donors SIN-1 and SNAP promote nonrapid-eye- movement sleep in rats. Brain Res. Bull. 41:293-298, 1996.
Ayers, N.A, L. Kapás, and J. M. Krueger. Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain. Brain Res. 707:127-130, 1996.
Chang, H.-Y. and L. Kapás. The effects of CCK-4 and non-sulfated CCK-8 on sleep, EEG slow-wave activity and brain temperature in rats, Physiol. Behav., 62:175-179, 1997.
Hansen, M., L. Kapás, J. Fang, and J. M. Krueger. Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats, Am. J. Physiol., 274:R168-R174, 1998.
Obál, F. Jr., L. Kapás, B. Bodosi, and J. M. Krueger. Changes in sleep response to intracerebral injection of insulin-like growth factor-1 (IGF-1) in the rat, Sleep Res. Online, 1:87-91, 1998.
Kapás, L., M. K. Hansen, H.-Y. Chang, and J. M. Krueger. Vagotomy attenuates but does not prevent the somnogenic and febrile effects of lipopolysaccharide in rats, Am. J. Physiol., 274: R406-R411, 1998.
Roky, R., L. Kapás, P. Taishi, J. Fang, and J.M. Krueger. Food restriction alters the diurnal distribution of sleep in rats. Physiol. Behav., 67:697-703, 1999.
Ribeiro, A. C, J. Gilligan,
and L. Kapás. Systemic injection of
a nitric oxide synthase inhibitor suppresses sleep responses to sleep deprivation
in rats. Am. J. Physiol., 278:R1048-R1056, 2000.
in my laboratory is focused on the biochemical – hormonal mechanisms
of sleep regulation. Currently, there are two
major areas of studies. The first addresses the role of nitric oxide in
homeostatic and circadian regulation of sleep. Our laboratory was
the first to describe that inhibitors of nitric oxide synthase suppress
sleep, nitric oxide donors stimulate sleep, and the activity of nitric
oxide synthase shows a diurnal variation. The second project addresses
the role of gastrointestinal hormones in sleep regulation. We hypothesize
that somnogenic gastrointestinal hormones such as cholecystokinin and insulin
form a regulatory network and modulate vigilance in various forms of satiety.