Levente Kapás, M.D.
Associate Professor

Department of Biological Sciences
Fordham University
441 E. Fordham Road
Bronx, NY 10458

E-mail:  kapas@fordham.edu
Phone:   718-817-3891
Fax:       718-817-3645

Selected Publications Research Interest
Kapás, L., F. Obál, Jr., P. Alföldi, G. Rubicsek, B. Penke, and F. Obál.  Effects of  nocturnal intraperitoneal administration of cholecystokinin in rats: simultaneous increase in sleep, increase in EEG slow-wave activity, reduction of motor activity, suppression of eating, and decrease in brain temperature.  Brain Res. 438: 155-164, 1988.

Kapás, L., L. Payne, F. Obál, Jr., M. Opp, L. Johannsen, and J. M. Krueger.  Sleep in diabetic rats:  effects of interleukin 1.  Am. J. Physiol. 260: R995-R999, 1991.

Kapás, L., L. Hong, A. Cady, M. R. Opp, A. E. Postlethwaite, J. M. Seyer, and J. M. Krueger. Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factora (TNFa), and TNFa fragments.  Am. J. Physiol. 263: R708-R715, 1992.

Kapás, L., M. Shibata, M. Kimura, and J. M. Krueger.  Inhibition of nitric oxide synthesis suppresses sleep in rabbits.  Am. J. Physiol. 266: R151-R157, 1994.

Kapás, L., F. Obál Jr., A. A. Book, J. B. Schweitzer, R. G. Wiley, and J. M. Krueger. The effects of immunolesion of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep, Brain Res., 712:53-59, 1996.

Kapás, L. and J. M. Krueger.  Nitric oxide donors SIN-1 and SNAP promote nonrapid-eye- movement sleep in rats.  Brain Res. Bull. 41:293-298, 1996.

Ayers, N.A, L. Kapás, and J. M. Krueger.  Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain.  Brain Res. 707:127-130, 1996.

Chang, H.-Y. and L. Kapás. The effects of CCK-4 and non-sulfated CCK-8 on sleep, EEG slow-wave activity and brain temperature in rats, Physiol. Behav., 62:175-179, 1997.

Hansen, M., L. Kapás, J. Fang, and J. M. Krueger.  Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats, Am. J. Physiol., 274:R168-R174, 1998.

Obál, F. Jr., L. Kapás, B. Bodosi, and J. M. Krueger.  Changes in sleep response to intracerebral injection of insulin-like growth factor-1 (IGF-1) in the rat, Sleep Res. Online, 1:87-91, 1998.

Kapás, L., M. K. Hansen, H.-Y. Chang, and J. M. Krueger.  Vagotomy attenuates but does not prevent the somnogenic and febrile effects of lipopolysaccharide in rats, Am. J. Physiol., 274: R406-R411, 1998.

Roky, R., L. Kapás, P. Taishi, J. Fang, and J.M. Krueger.  Food restriction alters the diurnal distribution of sleep in rats.  Physiol. Behav., 67:697-703, 1999.

Ribeiro, A. C, J. Gilligan, and L. Kapás.  Systemic injection of a nitric oxide synthase inhibitor suppresses sleep responses to sleep deprivation in rats.  Am. J. Physiol., 278:R1048-R1056, 2000.
Full List of Publications

Medline List of Publications

Recent Abstracts
APSS Meeting 2000

APSS Meeting 2001



The research in my laboratory is focused on the biochemical – hormonal  mechanisms of sleep regulation. Currently, there are two major areas of studies. The first addresses the role of nitric oxide in homeostatic and circadian regulation of sleep.  Our laboratory was the first to describe that inhibitors of nitric oxide synthase suppress sleep, nitric oxide donors stimulate sleep, and the activity of nitric oxide synthase shows a diurnal variation.  The second project addresses the role of gastrointestinal hormones in sleep regulation.  We hypothesize that somnogenic gastrointestinal hormones such as cholecystokinin and insulin form a regulatory network and modulate vigilance in various forms of satiety. 
Biographical Sketch
Szeged Medical University, Hungary (today: University of Szeged, Albert Szent-Györgyi Medical and Pharmaceutical Center), 1985: M.D., summa cum laude
1985 - 1989: Instructor, Department of Physiology, Szeged Medical University, Hungary 
1989 - 1992:
Postdoctoral Research Associate, Department of Physiology and  Biophysics, University of Tennessee, Health Science Center, Memphis
1992 - 1996: 
Assistant Professor, Department of Physiology and Biophysics, University of Tennessee, Memphis, TN
1996 - present: 
Associate Professor, Department of Biological Sciences, Fordham University, New York
The Lab
My Mentors
Current lab members

Past lab members

Human Physiology


Ferenc Obál

James Krueger

Fordham University

Department of Biological Sciences

Sleep on the Internet
Sleep Home Pages

World Federation of Sleep Research Societies (WFSRS)
European Sleep Research Society (ESRS)
Associated Professional Sleep Societies (APSS)
Sleep Research Society (SRS)

Sleep Research Laboratory, Lyon, France

Educational Resources
A short, non-techical introduction to sleep from the Encarta Encyclopedia

Sleep Syllabus:  an excellent introduction to sleep for sleep trainees

The Chapter on sleep from the book "Principles of Neuroscience"

Human Frontier Science Program workshop report:  The Regulation of Sleep, and excellent handbook for sleep scientists.  Downloadable in PDF format.

The Solitary Cedar by Tivadar Csontváry Kosztka