Pulmonary embolusDefinition A pulmonary embolus is a blockage of an artery in the lungs by fat, air, clumped tumor cells, or a blood clot. Causes, incidence, and risk factors Pulmonary emboli are most often caused by blood clots in the veins, especially veins in the legs or in the pelvis (hips). More rarely, air bubbles, fat droplets, amniotic fluid, or clumps of parasites or tumor cells may obstruct the pulmonary vessels. The most common cause of a pulmonary embolism is a blood clot in the veins of the legs, called a deep vein thrombosis (DVT). Many clear up on their own, though some may cause severe illness or even death. Risk factors for a pulmonary embolus include:
Persons with certain clotting disorders may also have a higher risk. Symptoms Symptoms of pulmonary embolism may be vague, or they may resemble symptoms associated with other diseases. Symptoms can include:
Signs and tests Tests to evaluate the function of the lungs:
An ECG may show abnormalities caused by strain on the heart. This disease may also alter the results of the following tests:
Treatment Emergency treatment and hospitalization are necessary. In cases of severe, life-threatening pulmonary embolism, definitive treatment consists of dissolving the clot with thrombolytic therapy. Anticoagulant therapy prevents the formation of more clots and allows the body to re-absorb the existing clots faster. Thrombolytic therapy (clot-dissolving medication) includes streptokinase, urokinase, or t-PA. Anticoagulation therapy (clot-preventing medication) consists of heparin by intravenous infusion initially, then oral warfarin (Coumadin). Subcutaneous low-molecular weight heparin is often substituted for intravenous heparin in many circumstances. In patients who cannot tolerate anticoagulation therapy, an inferior vena cava filter (IVC filter) may be placed. This device, placed in the main central vein in the abdomen, is designed to block large clots from traveling into the pulmonary vessels. Oxygen therapy may be required to maintain normal oxygen concentrations. Surgery is sometimes needed in patients at great risk for recurrent embolism. Expectations (prognosis) It is difficult to predict how the patient will do in the future. Often, the outlook is related to the disease that puts the person at risk for pulmonary embolism (for example, cancer, major surgery, trauma). In cases of severe pulmonary embolism, where shock and heart failure occur, the death rate may be greater than 50%. Complications
Calling your health care provider Go to the emergency room or call the local emergency number (such as 911) if symptoms of pulmonary embolus occur. Prevention Prevention of deep venous thrombosis (DVT) among at-risk patients is very important. Walking and staying active as soon as possible after surgery or during a prolonged medical illness can reduce the risk for pulmonary embolus. Heparin therapy (low doses of heparin injected under the skin) may be used for those on prolonged bedrest. Other preventive measures include compression stockings (plastic sleeves that fit around the legs and help circulate the blood). Illustrations
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