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Newswise reviews on virus software Medical News feline leukemia virus treatment | Tibotec Begins Enrollment for Phase III Study of Telaprevir Username: Password: forgotten login how to register ABOUT NEWSWISE Overview of Services Media Subscribers Source Institutions What's New Contact Us LIBRARIES Latest News SciNews MedNews LifeNews BizNews Video/Audio RSS Feeds Search CHANNELS Breaking News Features RESOURCES Expert Finder Tools Contact Directory Meetings Calendars Awards for Journalists Grants for Journalists SUPPORT Newswise Community How to Register © Newswise. All Rights Reserved. Source: Zeno Group, DC Released: Wed 15-Oct-2008, 08:00 ET Embargo expired: Wed 15-Oct-2008, 08:00 ET Printer-friendly Version Tibotec Begins Enrollment for Phase III Study of Telaprevir Libraries Medical News Keywords HEPATITIS C Contact Information Available for logged-in reporters only Description Tibotec BVBA announced today that it has begun ca virus enrolling patients in its phase III clinical trial evaluating telaprevir, an investigational hepatitis C virus protease inhibitor, in patients who failed prior therapy with peginterferon (Peg-IFN) plus ribavarin (RBV). The trial, known as REALIZE, will compare the efficacy, safety and tolerability of telaprevir combined with Peg-IFN plus RBV versus Peg-IFN and RBV alone, the current standard of care. Investigators at U.S. trial centers have begun screening patients Reviews Of Intego Virus Barrier Software for participation in the study, with global centers expected to begin screening in the coming weeks. Newswise — Tibotec BVBA announced today that it has begun enrolling virus informatico patients in its phase III clinical trial evaluating virus scanning program telaprevir, an investigational hepatitis C virus protease inhibitor, in patients who failed prior therapy with peginterferon (Peg-IFN) plus ribavarin (RBV). The trial, known as REALIZE, will compare the efficacy, safety and tolerability of telaprevir combined with Peg-IFN plus porn sites virus RBV versus Peg-IFN and RBV Best Virus Protection Program alone, the current standard of care. Investigators at U.S. trial centers ebola virus origin have begun screening patients for participation in the study, with global centers expected Microsoft Virus Current to begin screening new computer virus in the coming weeks. Telaprevir is being co-developed by Vertex Pharmaceuticals Incorporated and Tibotec. Tibotec, the sponsor of the REALIZE trial, is
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managing the trial worldwide. “We are excited about the ongoing development of telaprevir, potentially the first direct antiviral for the treatment of HCV, which may provide a new option for patients who have Removing Virus failed the current standardfree virus scanning and deleting
of care,” said Roger Pomerantz, MD, President, Tibotec Research and Development. “We are committed to examining the safety and efficacy of telaprevir through command anti virus phase avg free virus scan III trials and look forward to working with health authorities with the goal of making this therapy available to HCV infected patients.” The REALIZE trial (Re-treatment of Patients with Telaprevir-based compare anti virus program Regimen to Optimize Outcomes) is a phase III, randomized, placebo-controlled double-blind study conducted over 72 weeks to ipaq virus examine two regimens of 750 mg telaprevir every eight hours (with and without a delayed start) combined with Peg-IFN and RBV versus Peg-IFN best virus protection and RBV alone. To be eligible for the study, patients must belong Free Norton Antivirus Virus Definition to one of the following three groups: - Null responders (defined as patients who achieved <2 log reduction in HCV RNA at week 12 of prior therapy); - Partial responders (defined as patients who achieved at least a 2 log reduction at week 12, but never achieved undetectable HCV RNA during prior therapy); and - Relapsers (defined as patients who had undetectable HCV RNA at the completion of blackmail virus at least 42 weeks of prior treatment, but relapsed during follow-up). The trial will enroll approximately 650 HCV patients at more than 30 centers in the U.S., 50 centers in Europe and 20 centers in the rest of the world. The study will include 300 null- and partial-responder patients and 350 patients with viral relapse. REALIZE is the first phase III study to evaluate a direct antiviral (or STAT-C) treatment forvirus s
HCV in null responder patients. The primary endpoint of the REALIZE study is sustained virologic response (SVR), defined as undetectable kat virus HCV Coxackie Virus RNA (<10 IU/mL) 24 weeks after the completion of how to uninstall avg virus program treatment. kmip virus Patients enrolled in this study will be randomized to three treatment arms: 1. Telaprevir Virus Immunity dosed at 750 mg every eight hours (q8h) for 12 weeks in combination with standard doses of avg virus protection Peg-IFN and RBV, followed by 36 weeks of treatment with Peg-IFN and RBV alone; 2. Delayed start arm, comprised of four weeks of treatment with Peg-IFN and RBV, followed by telaprevir dosed at 750 mg q8h for 12 weeks in combination with standard doses of Peg-IFN and RBV, followed by another 32 weeks of Peg-IFN and RBV alone; or 3. A computer virus name control arm with standard doses adeno virus of Peg-IFN and RBV dosed for 48 weeks. Patients in worst human virus known to man all Flu Burung Virus Definition treatment arms will be followed for 24 weeks after completion of treatment to assess SVR. For additional information on inclusion and exclusion criteria for this study, please see www.clinicaltrials.gov. The REALIZE phase III study in treatment failure patients windows virus is part of a comprehensive clinical development program for telaprevir. Vertex is managing the ADVANCE phase III trial in treatment-naïve patients. Tibotec has the anti virus vista right to develop and commercialize telaprevir in Europe, South America, the Middle East, Africa, India, Australia and New Zealand. Vertex will commercialize telaprevir in the U.S., Canada and Mexico. As a trendmicro free virus scan global virology leader committed to patient care, Tibotec uses anti virus internet security innovative science and expertise to research, develop, manufacture and market drugs of unmet need. Tibotec is dedicated to building a portfolio of novel antiviral therapies to address completamente gratis removedor de virus the significant unmet needs of patients with chronic hepatitis C. In addition to its partnership with Vertex to develop do virus attack macintosh and commercialize telaprevir, Tibotec is currently developing with partner Medivir a second potential treatment for HCV which is in early stage trials. Through the application of its deep understanding of virology and viral resistance, Tibotec has become an established leader in HIV/AIDS, having gre virus scan developed and made available two antiretroviral agents for the treatment of HIV. Tibotec continues its commitment to developing novel therapies through a robust research and development program, which includes a third anti-HIV treatment as wellnuro virus
as a potential treatment for tuberculosis. About Tibotec BVBA Tibotec BVBA is a global pharmaceutical and research development company. The Company’s main research and development facilities are in Mechelen, Belgium with offices in Yardley, Pa. and Cork, Ireland. Tibotec is dedicated to the discovery and development stop emailing me virus of innovative HIV/AIDS and hepatitis C drugs, and anti-infectives for diseases of high unmet how to remove aconti virus medical need. Forward Looking Statement This press release contains "forward-looking statements" digstream virus as defined in the Private Securities Litigation Reform Act of 1995. These statements are based on current expectations of future events. If underlying master boot record virus assumptions prove inaccurate or unknown risks or uncertainties materialize, free online virus scanners actual results could vary materially from Tibotec BVBA’s expectations and free online virus scan projections. Risks and uncertainties include general industry conditions and competition; economic conditions, such herpes virus outside the body as interest rate and currency exchange rate fluctuations; technological advances and patents human cancer virus attained by competitors; challenges inherent in new product development, including obtaining regulatory approvals; domestic and foreign health care reforms and governmental laws and regulations; and trends toward computer virus locks up computer health care cost containment. A further list and description of these risks, uncertainties and other factors can be found in Exhibit 99 of Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended December 31, 2006. Copies of this Form 10-K, as well as subsequent filings, are available online at www.sec.gov, www.jnj.com or on request from Tibotec BVBA or Johnson & Johnson.n barr virus
Tibotec BVBA does not undertake to update any forward-looking statements as a result of new information or future events or developments. Tibotec is a member of the Johnson & Johnson family of companies. © 2008 Newswise. All Rights Reserved.West Nile virus confirmed in Bayonne man - Hudson County - NJ.com
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