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Iran's former President Seyyed Mohammad Khatami waves during a meeting named Yazd, the cradle of ancient civilization and symbol of dialogue, in Yazd city 795Km (495 Miles) southeast of Tehran, Iran on October 15, 2008. Khatami, a reformist born in Yazd, was president of Iran from 1997-2005. (UPI xp virus Photo/Mohammad Kheirkhah) | Slideshow
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Out-licensing: Multiplex Microarray for Simultaneous Detection of Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus Type-1
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Multiplex Microarray for Simultaneous Detection of Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus Type-1
Specific and sensitive microarray and multiplex assay for the simultaneous detection and discrimination of HCV, HBV, and HIV-1, which include Ypolio Virus Family And Shape both RNA and DNA genomes.
Full description
Available for licensing and commercial development are patent rights that cover a specific and sensitive microarray (TTD -V-1) and multiplex assay for the simultaneous detection and discrimination of Hepatitis C Virus (HCV), Hepatitis B Virus (HBV) and Human Immunodeficiency Virus Type-1 (HIV-1), which include both RNA and DNA genomes. Four specific probes (30-45 bp oligonucleotides) for each of these three viruses as well as the two internal controls were designed. Totally, each Free Virus Scan Windows microarray consists of 20 probes immobilized on silylated glass slides. The single-stranded Cy5-labeled samples for microarray hybridization were obtained from labeling the amplicons using primer extension thermocycling. The multiplex microarray assay was able to detect and discriminate as low as 3 pan susceptible virus copies of genotypes A, B, C, D, Online Virus Sacn and 10 copies of genotype E of HBV, 10 copies of HCV (genotype 1b), and 20 copies of HIV-1 (group M, subtype B) in a single multiplex reaction. virus source code The microarray assay could also detect the coexistence of two or three of these viruses and discriminate them simultaneously. The results of this study demonstrated the feasibility and performance of microarray-based multiplex detection of the three viruses, HCV, HBV, and HIV-1 in comparison with conventional individual PCR and virus encyclopedia gel electrophoresis Disadvantages Of The Worm Virus technique.
Patent information
U.S. Provisional Application No. 60/759,214 filed 17 Jan 2006 (HHS Reference No. E-077-2006/0-US-01) Inventors: Chu Chieh Xia, Gerardo Kaplan, Hira Nakhasi, Amy Yang, Raj Puri (FDA)
Type of business relationship sought
Licensees sought: Available for non-exclusive or exclusive licensing. Collaborative Research virus scanners Opportunity: The Food and Drug Administration's Center for Biologics Evaluation and Research (CBER) is seeking statements of capability or interest from parties interested in collaborative research to further avast virus scanner develop, evaluate, or commercialize this technology. Please contact Beatrice Droke, virus protect Technology Development Coordinator, FDA, (301) 827-7008 for more information.
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Michael Shmilovich
Senior Licensing and Patenting Manager
Office of Technology Transfer
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National Institutes of Health (NIH)
NIH achieves its mission of improving human health through a combination of biomedical research, training, and communication.
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