Biochem. buying steroids online cheapPictures of steroid abuse. J. , 1982, 201, 569. 11. buying steroids online cheapSteroid-side-affects. Chem. Pharm. Bull. buying steroids online cheapMediterranian diet. , 8, pgs. 84-85. Upon reading this information, Dr. Donike (at the time director of the IOC accredited Cologne laboratory, and head honcho as far as IOC drug testing) and several others wrote me saying that I was completely misguided, and that my "rantings" about a possible endogenous origin for nandrolone metabolites in athletes were preposterous and totally unsubstantiated by present knowledge and research. This unreasonable reaction to my writing and researching is typical of an organization that operates while wearing blinders. One that is unwilling to admit because of the moral and legal repercussions, that they may be some leeway and that they might be mistaken. Endogenous Production of Nandrolone and Its MetabolitesThe fact is that a number of studies have since shown that norandrosterone (NA) and noretiocholanolone (NE) (and likely nandrolone itself) are endogenous steroids formed likely from gonadal, adrenal and peripheral steroidogenic pathways. (Kicman & Brooks 1988; Debruyckere et al. 1990, Le Bizec et al. 1999, Dehennin et al. 1999). Thus, since NA and NE are endogenous steroids, it's not the presence of nandrolone metabolites that constitutes a positive drug test for nandrolone. As such, we need to be able to distinguish the natural endogenous products from the exogenous ones, including the anabolic steroid nandrolone and the various prohormones such as norandrostenedione and norandrostenediol. To this end, the IOC and other sporting federations have decided to establish a urinary threshold concentration above which constitutes a positive doping test for the anabolic steroid nandrolone and/or one or more of the prohormones. And this is where the major problem lies. Unfortunately for the athletes, establishing a urinary threshold level for nandrolone metabolites is currently a difficult and speculative process, due largely to the lack of scientific knowledge within this area. For example, endogenous production has been shown in several studies to vary and has been found to be as high as 37 ng per ml in male subjects. (Debruyckere et al. , 1990) No specific studies have been undertaken to determine excretion rates in females, although it has been demonstrated that natural female urinary NA concentrations are significantly higher than males (Ciardi et al. 1999). Use of a threshold level also becomes difficult when environmental and physiological stress results in changes in the excretion rate of steroidal metabolites. Recent work by Le Bizec et al.