Table of contents:
Preface
Introduction
Inactivating Events: LOH, Point Mutations, Methylation
TP53: A Major Tumor Suppressor Gene in (Breast) Cancer
BRCA1 and BRCA2, Major Tumor Suppressor Genes in Familial Breast Cancer
Detailed Information on Candidate Tumor Suppressor Genes
Conclusions
Acknowledgments
Index
Candidate Tumor suppressor Genes discussed:
On chromosome 1: CLCA2, DIRAS3 (ARHI, RHOI, NOEY2), LPHH1, TTC4, RAD54L (RAD54), FABP3 (MDGI), RUNX3 (CBFA3, AML2), PRDM2 transcript 1 (RIZ transcript 1), SFN (14-3-3s)
On chromosome 3: ROBO1 (DUTT1), PTPG (PTPRG); FHIT (FRA3B, included), PB1 (BAF180), RASSF1 transcript A, RBM5 (LUCA-15, H37), TUSC4 (NPRL2), TMEM158 (RIS1), SEMA3B, TGFBR2 (HNPCC6), APRG1 (C3ORF35), RARB transcript 2, VHL, ATR (FRP1)
On chromosome 4: SLIT2, PRDM5, HPGD (PGDH1)
On chromosome 5: DAB2 (C9), APC, IRF1
On chromosome 6: PLAGL1 (ZAC, LOT1), LATS1 (WARTS), IGF2R (MPRI)
On chromosome 7: ST7 (TSG7, RAY1, FAM4A1, HELG)
On chromosome 8: SFRP1 (FRP), DLC1 (ARHGAP7), BNIP3L, RHOBTB2 (DBC2), LZTS1 (FEZ1, F37), MTUS1 (ATIP), MCPH1 (BRIT1), ST18
On chromosome 9: CDKN2A (p16INK4A, p14ARF), SYK, DAB2IP (AIP1), TSC1
On chromosome 10: PTEN (MMAC1), PDCD4, MGMT
On chromosome 11: WT1, TSG101, CDKN1C (BWS), CST6, IGSF4 (TSLC1, ST17, NECL2), ATM, LOH11CR2A (BCSC1)
On chromosome 12: CCND2
On chromosome 13: LATS2, BRCA2 (FANCD1), RB1, ARL11 (ARLTS1)
On chromosome 15: RAD51 (RECA)
On chromosome 16: TSC2, CYLD, CTCF, CDH1, TERF2 (TRF2), TERFIP, FBXL8, LRRC29, ATBF1, WWOX, FBXO31, CBFA2T3 transcript B (MTG16), CPNE7, CDK10 (PISSLRE), FANCA, GAS11, C16ORF3
On chromosome 17: MAP2K4 (SERK1, SEK1, PRKMK4, MEK4), GABARAP, TP53, HIC1, OVCA1(DPH1, DPH2L1), BRCA1, BECN1, SLC9A3R1
On chromosome 18: EPB41L3, SMAD4 (ELAC1, DPC4), DCC
On chromosome 19: STK11 (LKB1)
On chromosome 22: SMARCB1 (BAF47, SNF5), RRP22, TMPRSS6, CHEK2 (CHK2, RAD53), NF2, PRR5
