DISSEMINATED TUMOR CELLS: DETECTION, MARKERS AND PROGNOSTIC/PREDICTIVE SIGNIFICANCE.TUMOR SUPPRESSOR GENES IN BREAST CANCER (book).
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POOR USAGE OF HUGO STANDARD GENE NOMENCLATURE IN CANCER MARKER STUDIES.


Marc Lacroix
International Journal of Biological Markers (2008) 23, 123-126

   Since 1989, the Human Genome Organisation (HUGO) attempts to ensure that for each gene there is one name and one symbol. The resulting standard nomenclature is, however, poorly applied in clinical studies, which impairs the efficient retrieval of information. This lack of support is reflected in the present survey of 303 articles (from 106 journals) reporting on disseminated tumour cell detection.


HUGO gene symbol (number of abstracts citing this symbol / total number of abstracts citing the marker)
HUGO gene name (number of abstracts citing this name / total number of abstracts citing the marker)
Frequently-used non-standard names and symbols(“aliases”)
Type of cancer
ANKRD30A (0 / 5) Ankyrin repeat domain 30A (0 / 5) B726; B726P; NY-BR-1 Breast
CEACAM5 (2 / 64) Carcinoembryonic antigen-related cell adhesion molecule 5 (2 / 64) Carcinoembryonic antigen; CEA Breast, Colorectal, Esophagus, Gastric, Head & Neck, Lung, Pancreas, Thyroid
DCT (0 / 2) Dopachrome tautomerase (0 / 2) Tyrosinase-related protein-2; TRP-2 Melanoma
EGFR (14 / 15) Epidermal growth factor receptor (15 / 15) EGF-R Bladder, Breast, Cervical, Colorectal, Head & Neck, Lung, Prostate
FOLH1 (0 / 6) Folate hydrolase 1 (0 / 6) Prostate-specific membrane antigen; PSM; PSMA Prostate
GUCY2C (0 / 4) Guanylate cyclase 2C (0 / 4) Guanylyl cyclase C; guanylylcyclase C; GCC Colorectal
KLK3 (1 / 14) Kallikrein-related peptidase 3 (1 / 14) Prostate specific antigen; prostate-specific antigen; PSA Prostate
KRT7 (0 / 5) Keratin 7 (0 / 5) Cytokeratin 7; CK7; CK-7 Breast, Esophagus, Lung, Ovary
KRT19 (1 / 77) Keratin 19 (1 / 77) Cytokeratin 19; cytokeratin-19; CK19; CK-19 Bladder, Breast, Cervical, Colorectal, Esophagus, Gastric, Head & Neck, Lung, Ovary, Pancreas, Thyroid
KRT20 (1 / 68) Keratin 20 (1 / 68) Cytokeratin 20; Cytokeratin-20; CK20; CK-20; CK 20 Bladder, Breast, Cervical, Colorectal, Esophagus, Gastric, Head & Neck, Lung, Ovary, Pancreas, Thyroid
MLANA (0 / 17) Melan-A (7 / 17) Melanoma antigen recognized by T cells 1; MART1, MART-1 Melanoma
MUC1 (13 / 20) Mucin 1 (12 / 20) Mucin type I; polymorphic epithelial mucin; EMA; MUC-1; MUC 1 Breast, Colorectal, Gastric, Lung
MUCL1 (0 / 2) Mucin-like 1 (0 / 2) Small mucin-like protein; small breast epithelial mucin; BS106; SBEM Breast
OR51E2 (0 / 2) Olfactory receptor, family 51, subfamily E, member 2 (0 / 2) Prostate-specific G protein coupled receptor; prostate-specific gene with homology to G protein receptor; PSGR; STAG1/PMEPA1 Prostate
PLUNC (0 / 2) Palate, lung and nasal epithelium carcinoma associated (0 / 2) Lung-specific X-protein; lunx Lung
SCGB2A1 (0 / 8) Secretoglobin family 2A, member 1 (0 / 8) Mammaglobin B; mammaglobin-B; mammaglobin 2; mamB; MGB2 Breast
SCGB2A2 (0 / 34) Secretoglobin family 2A, member 2 (0 / 34) Mammaglobin; mammaglobin A; mammaglobin 1; MAM; mam; hMAM; hMAM-A; MG; MGB1; MMG Breast
SERPINB3 (0 / 4) Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 (0 / 4) Squamous cell carcinoma antigen 1; SCCA1; SCC Esophagus, Head & Neck
SERPINB4 (0 / 1) Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4 (0 / 1) Squamous cell carcinoma antigen 2; SCCA2 Esophagus, Head & Neck
SERPINB5 (0 / 12) Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 (0 / 12) Maspin; MAS Breast
SILV (0 / 3) Silver homolog (mouse) (0 / 3) Gp100; GP-100 Melanoma
TACSTD1 (3 / 13) Tumor-associated calcium signal transducer 1 (3 / 13) Epithelial glycoprotein 2; epithelial glycoprotein 40; EGP40; EGP2; KS1/4; GA733-2 Breast, Colorectal, Esophagus, Lung
TERT (0 / 13) Telomerase reverse transcriptase (11 / 15) hTERT; h-TERT Breast, Colorectal, Liver, Melanoma, Stomach, Thyroid
TFF1 (1 / 4) Trefoil factor 1 (1 / 4) PS2 Breast
UCHL1 (0 / 2) Ubiquitin carboxyl-terminal esterase L1 (0 / 2) Ubiquitin thiolesterase; PGP 9.5 Lung



Type of cancer Number of articles and period covered
Breast 89 articles, between 1999 and 2008
Liver 22 articles, between 2002 and 2007
Lung 19 articles, between 1999 and 2007
Melanoma 34 articles, between 1999 and 2007
Ovary 4 articles, between 2000 and 2006
Prostate 19 articles, between 2002 and 2007
Bladder 14 articles, between 1998 and 2006
Cervical 3 articles, between 1999 and 2007
Colorectal 51 articles, between 2000 and 2007
Esophagus 10 articles, between 2003 and 2007
Gastric 25 articles, between 1999 and 2007
Head & Neck 4 articles, between 1999 and 2007
Pancreas 8 articles, between 1999 and 2007
Kidney 5 articles, between 2003 and 2006
Thyroid 16 articles, between 2000 and 2006



Journals examined
Acta Biochimica Polonica
Acta Obstetricia et Gynecologica
Aktuelle Urologie
Alimentary Pharmacology & Therapeutics
American Journal of Clinical Oncology
American Journal of Clinical Pathology
American Journal of Gastroenterology
American Journal of Respiratory and Critical Care Medicine
Annals of Oncology
Annals of Surgery
Annals of Surgical Oncology
Annals of the New York Academy of Sciences
Anticancer Research
ANZ Journal of Surgery
Archives of Gynecology and Obstetrics
Archives of Surgery
BJU International
BMC Cancer
Bone Marrow Transplantation
Breast
Breast Cancer Research
Breast Cancer Research and Treatment
British Journal of Cancer
British Journal of Surgery
Cancer
Cancer Detection & Prevention
Cancer Letters
Cancer Research
Cancer Science
Clinica Chimica Acta
Clinical Biochemistry
Clinical Cancer Research
Clinical Chemistry
Clinical Chemistry and Laboratory Medecine
Clinical Colorectal Cancer
Clinical & Experimental Metastasis
Critical Reviews in Clinical Laboratory Sciences
Croatian Medical Journal
Digestive Diseases
Disease Markers
Diseases of the Esophagus
Diseases of the Colon and Rectum
European Journal of Cancer
European Journal of Cardiothoracic Surgery
European Journal of Endocrinology
European Journal of Surgical Oncology
European Respiratory Journal
European Urology
Experimental and Molecular Medicine
Gastric Cancer
Gynecologic Oncology
Hepatobiliary & Pancreatic Diseases International
Hepatology
International Journal of Biological Markers
International Journal of Cancer
International Journal of Colorectal Diseases
International Journal of Immunopathology and Pharmacology
International Journal of Molecular Medecine
International Journal of Oncology
International Journal of Urology
Japanese Journal of Cancer Research
Japanese Journal of Clinical Oncology
Journal of Biochemistry and Molecular Biology
Journal of Cancer Research and Clinical Oncology
Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Oncology
Journal of Clinical Pathology
Journal of Dermatological Science
Journal of Experimental & Clinical Cancer Research
Journal of Gastroenterology and Hepatology
Journal of Hematotherapy & Stem Cell Research
Journal of Immunological Methods
Journal of Investigative Dermatology
Journal of Molecular Diagnostics
Journal of Molecular Medecine
Journal of Pathology
Journal of Urology
Laboratory Investigations
Langenbecks Archives of Surgery
Lung Cancer
Melanoma Research
Molecular Diagnosis and Therapy
Molecular Diagnostic
Molecular Pathology
Neoplasia
Neoplasma
Oncology
Oncology Reports
Pathology International
Plastic Reconstruction Surgery
Prostate Cancer and Prostatic Diseases
Respiratory Medicine
Scandinavian Journal of Gastroenterology
Seminars in Surgical Oncology
Surgery
Surgery Today
Surgical Endoscopy
Thyroid
Transplantation International
Transplantation Proceedings
Tumour Biology
Ultrasound Medicine and Biology
Urological Oncology
Urology
World Journal of Gastroenterology
World Journal of Surgery

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