Iatrogenic Stemetil Poisoning
by Malcolm Everett Friday April 08, 2005 at 03:31 AM
meverett2@hotmail.com Northern Ontario

Neuroleptics (antipsychotics) are among the most dangerous medications ever used in medicine, and Stemetil is no exception. They are presently prescribed haphazardly by psychiatrists and general practitioners alike. In simple words, they are brain damaging chemicals. http://www.meverett.com/index/stemetil4.htm

Prelininary Findings

All drugs are poisons and all poisons are (potentially) drugs: drug side effects rangie from the annoying to the lethal. There is also a physical tolerance and withdrawal syndrome (excitement seizures) , and a panic factor (iatrogenic) which can kill you.

Objective: To make a greater body of dawareness of ifinitive evidence available from all sources of information relating to the drug Stemetil that shows presence or absence of the characteristic drug signature (pattern of injury) , especially where injury is believed to be doctor caused.

Target focal point: Drug signature analysis/profiling of key drug induced toxicities in liver, kidney and heart tissue associated with phenothiazine type drugs. By using biomarkers of drug pathology and mechanisms from drug signature (pattern recognition) and multi-source library profiles I will demonstrate and show publicly that use of Stemetil for control of nausea can be an iatrogenic drug induced nightmare of unprecedented magnitude.

Biomarkers are genetic indicators that have been shown to be correlative with normal biologic processes, pathologic processes or pharmacologic responses to theraputic intervention.

Probable Valid Biomarkers are currently defined as those that have been measured in an analytical test system with well-established performance characteristics and for which there is a scientific framework or body of evidence that appears to elucidate the physiologic, toxocologic, pharmacologic or clinical significance of the test results.

Known Valid Biomarkers are currently defined as those that have been measured in an analytical test system with well-established performance characteristics and for which there is widespread agreement in the medical or scientific community about the physiologic, toxocologic, pharmacologic or clinical significance of the results.

The liver plays a major role in the biotransformation of drugs and toxins and thereby becomes a major target for drug-induced injury. But what about other vital organs?

Stemetil (prochlorperazine) is a high risk antipsychotic-antiemetic drug to be used with caution, and according to manufacturer's directives. The drug Stemetil is produced in Canada by Aventis Pharma

Stemetil is widely distributed into body tissues and fluids. Stemetil suppresses activity in the trigger zones of the vomiting center by paralyzing the gastrointestinal tract that governs the vomiting reflex. Stemetil undergoes metabolism in the gastric mucosa and on first pass through the liver where it enters the enterohepatic circulation and is excreted chiefly in the feces. Stemetil is diminished by its low bioavailability owing to a significant gastric and hepatic first pass effect. In the case of Arlene Berry, vomiting can be traced to bowel obstruction as evidenced by emesis of yellowish fluid, what is bilious vomit. Stemetil was contraindicated at the onset. Caveat: When everything in the intestine slows down, everything in it backs up. In this case it resulted in a significant backup of intestinal material, as evidenced by the medical record.

Each drug tends to have a signature, meaning a typical pattern of injury. In the case of phenothiazine type drugs, this pattern of injury closely mimics viral hepatitis, clinically, biochemically and histologically. Patients typically have a mixed cholestatic-hepatocellular picture as seen in both bilirubin and aminotransferase levels. But donÕt be fooled by normal liver enzyme levels. This is a typical feature of edited lab records by callous physicians to conceal evidence of iatrogenic injury. Turn the focus to mechanisms from drug-signature with emphasis on pattern recognition. Make a detailed list of all signs and symptoms for comparative analysis. If typical pattern of injury is present but the liver function findings tend to elucidate or do not support the facts you can be reasonably certain that the records have been messed with. This of course requires a high index of suspicion, but a simple test to confirm is to detail one topic at a time, the blood pressure, for example. List everything in chronological order according to time of event from all sources of the record. If one record documents a certain blood pressure at a certain time, and another record or chart documents something different for the very same time you know the record has been altered. Then go on to the heart rate, etc. Leave no stone unturned. By repeating the procedure from different sources you can turn the smallest clue into a material witness.

If the clinical presentation is consistent with a hepatitis-like picture and/or cholestatic reaction, the findings are compatible with drug signature. There are a variety of clinical syndromes which may in some situations overlap. Severe infection is no exception. Always be on the alert for common denominators.

My first finding with respect to the Arlene Berry Case was one of hepatic encephalopathy, due to possible drug induced liver failure presenting with all the characteristic features of hepatitis. In fact the signs and symptoms were indistinguishable from hepatitis. What I later uncovered was the presence of a toxic shock-like syndrome that may actually overlap pattern of injury associated with drug induced liver failure. TSS (Toxic Shock Syndrome) is a variant of septic shock and bacteremic shock. Adding to the confusion of sorting it all out, there was a mixed picture ranging from withdrawal from opiates to one of sepsis. Compare Viral Hepatitis. and Hepatic or Portal Systemic Encephalopathy with Toxic Shock Syndrome, and Sepsis. It will give an indication of what I am talking about.

A typical single dose of Stemetil for a small woman with a low body weight is 5 mg. According to the hospital record Arlene Berry was given 10 mg x 4.

Stemetil (prochlorperazine ) poisoning is marked by oversedation, respiratory depression and hypotension. Symptoms of overdosage include sedation, loss of consciousness or coma , hypotension, tachycardia, EEG changes, ventricylar arrhythmias, and hypothermia or temperature dysregulation which may mimic an afebrile state. With respect to the Arlene Berry Case all of these signs and symptoms were present. Although many of these signs and symptoms may overlap with certain conditions there are other ways of tracing pattern of injury, such as by systematic reviewing of all relevant literature and comparing it with the events documented on the medical record. You'll be surprised at what you can uncover. In the case of Arlene Berry, its what put the finger on the toxic shock syndrome. I later confirmed it by matching the blood values to staph. aureus with meningeal involvement, and to rule out metastatic cancer, while attempting to gather evidence of drug involvement.

Stemetil is highly bound to proteins in blood (91-99%) and has a duration of activity from 4 to 6 hours. One caveat is that the drug has a half life that can potentiate or even interact with concurrent medications, such as analgesics, for example.

Caveat: Blood borne infection or meningocci in the blood lyse easily. It seems logical to assume that Stemetil would be contraindicated to infection for this reason. CAVEAT:

Phenothiazines can potentiate and mask the signs and symptoms of overdosage of other drugs or underlying conditions, ie. organic brain syndrome, etc.. Thus patients can have exascerbation of their underlying or pre-existing conditions. The adverse effects of phenothiazines can affect all organ systems, and Stemetil is no exception; eyes, nose, and throat; internal organs such as liver, stomach, intestines, cardiovascular system, sexual organs, and especially the brain.

A great many patients suffer disastrous consequences, such as neuroleptic malignant syndrome, cardiovascular crisis, seizures, heatstroke, and sudden unexplained death, all of which can be attributed to medical stupidity and negligent use of phenothiazines, and their derivatives.

Phenothiazines type drugs are among the most dangerous medications ever used in medicine. Don't be fooled into believing that these drugs are actually treating a disease. They are suppressing overall brain and vital organ function, while creating diseases, and exascerbating illness, resulting in catastrophic decline of patient condition. Indications are primarily in the management of psychotic or mental disorders; also used to subdue patients - a chemical straightjacket. Reference: Psychiatric Insanity.

The antiemetic action of Stemetil may actually mask the signs and symptoms of drug overdosage and may obscure the diagnosis and treatment of other conditions, ie. intestinal obstruction. How could they even think to market such a dangerous drug? An how could Health Canada even permit it?

Toxic doses of Stemetil can lead to changes in the blood-brain barrier (BBB), allowing an infectious agent to gain entry to the brain and produce lethal central nervous system (CNS = brain and spinal cord) infection. The scientific literature describe two bacterial factors specific to the meningitis pathogen that thwart the normal protective role of the blood-brain barrier, leading to serious infection. Further, sugar solution in IV creates gaps in the blood-brain barrier allowing chemicals to enter. Infected material can block the blood vessels to the brain, but Stemetil can help shuttle it directly into the brain and CNS.

Stemetil (prochlorperazine) enhances permeability of the blood-brain barrier and crosses the blood-brain barrier, breaching BBB integrity, thus allowing penetration of normally excluded agents taking with it blood toxins and poisons in the blood-stream - which then triggers an inflamatory response. Bacteria invade the cerebrospinal fluid (CSF) by crossing the blood-brain barrier through a complex series of events, beginning with attachment of bacterial fibrils to the brain microvascular endothelial cells. Once in the CFS, bacteria multiply rapidly due to the absence of local defences where they further degrade the BBB and exascerbate tissue damage resulting in permanent brain injury.

Brain injury caused by drug induced meningitis related inflamation, edema, reduced blood flow (ischemia), or endogenous toxins can lead to neurologic sequalae, including deafness, mental retardation, motor dysfunction, and (secondary) epilepsy.

Stemetil is contraindicated to emesis in altered states of consciousness, coma, trauma, toxic syndromes, in the presence of blood dyscrasias, central respiratory failure, in the presence of circulatory collapse, in severely depressed patients, liver and renal insufficiency, intestinal obstruction, in patients with cardiovascular disorders, organic brain syndrome, or a history of hypersensitivity to phenothiazine derivatives.

Phenothiazines suppress sweating, causing central nervous system impairment in which coma is characteristic. Arlene Berry had gone into a coma following administration of Stemetil, first thought to be hepatic coma. According to the record, she was afebrile (without fever), which can infer temperature disregulation.

Stemetil contains a cardiotoxic metabolyte (having an injurious effect on the heart) which can lead to toxic myocarditis or drug induced cardiomyopathy, and subsequent heart failure. Current use of antipsychotic medications is associated with a more that tripled risk of Sudden Cardiac Death.

Stemetil is a high risk antipsychotic anti-emetic drug. Indications are primarily in the management of psychotic disorders. Stemetil (prochlorperazine) is the most potent in suppressing the reflex of nausea and vomiting. But that's not all it suppresses. Sudden deaths have occurred in hospitalized patients using this type of drug in which iatrogenic causes are suspect at the grass root level. In some cases, the deaths were attributed to cardiac arrest, while in others the cause appeared to be asphyxia due to failure of the cough reflex, the result of phenothiazine induced muscle paralysis.

Search: Identifying Drug-Induced Changes in Electrocardiogram - features individuals whose ECG's have been altered due to multiple pharmacological agents. Compare abnormal ST&T wave segment on ECG with adverse effects of the drug Stemetil as reported in the Compedium of Pharmaceuticals and Specialties (CPS) 2004.

Antipsychotic drugs may cause blood clots, researchers report extending previous findings. Prochlorperazine has been reported to cause heart attack, shock, stroke, and GI bleeding. Phenothiazine type drugs have even been reported to trigger diabetes in patients with no previous history of diabetes.. Neuroleptic agent toxicity in an already sedated patient can result in tachycardia, hyperthermia, urinary retension ileus, mydriasis (pupil dilation), hypoglycemia (becomes apparent as blood toxicity increases) toxic psychosis, and can even cause direct injury to the heart.

Drug Induced Dystonia is defined as a movement disorder characterized by sustained muscle contractions. freequently causing twisting and repetitive movements or abnormal postures that can result in distorted postures.It is a charcteristic feature with phenothiazine type reactions.

Dystonic reactions are thus acute spasms of muscle groups that can lead to a fixed upward gaze... painful dystonic reactions can be quite frightening to patients. These reactions typically occur soon after initiation of an antipsychotic drug. When that happens any negligence of the patientÕs throat secretions may lead to aspiration of vomitus or gastric content and a vicious cycle begins, which if not broken will lead to death.

In the case of Arlene Berry, the presenting symptoms occuring shortly after administration of Stemetil for control of nausea. are characterized by a twisting and distorted posturing as evidenced by the record, followed by sustained muscle contractions, which may resemble those of structural brain injury. Deep tendon reflexes were observed to be diffusely and symetrically brisk, plantar responses were extensor, and there was sustained clonus bilaterally. These findings are consistent with drugs or toxins that affect the basal ganglia, thalmus or brain stem. The list of drug induced dystonic reactions is long, but includes Stemetil.

Incontinence suggests loss of bladder control, or bladder paralysis, and is a very serious side effect of Stemetil, and possibly first sign of a drug reaction. The record at N-4 documents incontinent blood tinged urine at 0305 hours that is consistent with decreased urine output, a hallmark of impaired water excretion , in this case accompanied by hematuria (blood in urine).

Compare: Rapid-Onset Dystonia Parkinsonism (RDP), a rare form of dystonia also characterized by dystonic spasms in the limbs, with prominant involvement involvement of the speach and swallowing muscles. Symptoms can be sudden, occuring over hours. Suppression of the gag reflex due to swallowing difficulty attributed to muscle paralysis can result in aspiration of vomitus or gastric content and ultimately, in asphyxia.

Tardive dyskinesia (TD) is also characterized by involuntary movements of the arms and legs. TD is potentially irreversable. Spontaneous dyskinesia has occured as abnormal involuntary movements in persons who have never been previously exposed to antipsychotic medications. Opisthotonus Iis characterized by spasms of the body where the head and heels are bent backward and the body is bowed forward. It occurs with drug reactions triggered by IV infusions with drugs such as Stemetil. Compare Idiopathic spasmodic torticollis, a focal dystonia associated with neuroleptic drug toxicity.

Stemetil changes a variety of chemicals in the brain. The adverse effects of Stemetil can affect all organ systems and may be attributed either to the drugÕs effects on the central autonomic nervous system, or to hypersensitivity reactions to the drug-reaction. Increased sedation is a serious side effect of this type of agent.

Symptoms of overdosage include central nervous system (CNS) depression which may vary from simple lethargy to coma. Symptoms of overdosage may be more severe than usual side effects, or two or more of the following may occur together: Falling levels of consciousness or coma; convulsions (seizures); fast or slow heartbeat; large fixed dilated pupils (also associated with shift of brain tissue and transtentorial herniation); palor; dry skin; weak pulse; low blood pressure; tachycardia; trouble in urinating; twitching or jerking movements; and vomiting. Other possible manifestations include paralytic ileus, hepatic dysfunction, renal dysfunction, gastrointestinal disturbances, respiratory depression (breathing difficulty), cardiac arrhythmias (heart failure), skin rashes or fixed drug eruption, dry eyes, ocular gyric crisis (eyes rolling back into their orbits); and simptoms resembling Parkinson's disease .

Caveat: Anticholinergic agents such as Gravol, an antihistamine, in combination with Stenetil can inhibit gastrointestinal motility which can exascerbate gastrointestinal problems, such as constipation or bowel obstruction . When the bowel stops working the body gets toxic. The effects of anticholinergic drugs such as Gravol may be potentiated by neuroleptic type anti-emetics, such as Stemetil. Use of neuroleptics in combination with anticholinergic agents may also increase the risk of tardive dyskinesia. The effects of opiate ANALGESICS (morphine) may also be potentiated similarly with concomitant or concurrent Stemetil use. Moderate to severe drug-drug interaction with Stemetil (prochlorperazine) and Dimenhydrinate (Gravol) with additive effects when used in combination or concurrently is reported in the literature. Search: Anticholinergic Syndrome. Compare Antichollinergic Toxidrome.

Life threatening: Uncontrolled mucscle twitching characterized by stiffness or spasms of the muscles, swirling tongue movements or swelling of the tongue, difficulty swallowing are all common features of the Neuroleptic Malignant Syndrome (NMS). Neuroleptic Malignant Syndrome is characterized by alterations in consciousness, and autonomic instability, such as tachycardia, hypertension or hypotension.

Stemetil poisoning is marked by oversedation, respiratory depression and hypotension. All phenothiazines can potentiate and mask the signs and symptoms of overdosage of other drugs or underlying conditions, ie. hypotension, etc. Thus patients can have exascerbation of their underlying disorders.

Phenothiazines that are clearly contraindicated in a wide variety of medical conditions have no effect on systemic infection, EXCEPT TO EXASCERBATE PRIMARY or UNDERLYING CONDITIONS due to a whole array of clinical insults, any or all of which can trigger a procoagulation response which can ultimately lead to coma, circulatory collapse, and DEATH., which is also a major cause of unexplained sudden dealths in hospitalized patients, more so than most ostrich-like physicians care to admit.

The concept of a systemic inflamatory response syndrome expresses the notion that the body responds in certain ways to a variety of insults and negligent use of Stemetil is the ultimate clinical insult, physically, and neurologically. All virtues of phenothiazines can potentiate and exascerbate similar or like-virtues of other medications known to cause respiratory depression. In frail patients, as respiratory rate decreases, the patient becomes increasingly sedated. Morphine is one drug that can lead to respiratory depression. Concomitant or concurrent use of Stemetil can result in exascerbation of this condition.

Caveat: Prochlorperazine intoxication or poisoning can also cause deep physiologic depression that resembles and can mimic brain death. SEARCH: Brain Damaging Neuroleptic Drugs.

The neuromuscular blocking effects of neuroleptic drugs are many and include nerve paralysis including neuronitis of spinal nerves. There is also a panic factor which can result in heart failure and kill you. Remember: The heart is a muscle, as are other vital organs.

Compare drug induced Rhabdomyolysis in which drug-toxicity involves vital organs : kidney, liver, gastrointestinal tract and CNS , with skeletal muscles usually being less readily affected. Drug induced Rhabdomyolysis is the breakdown of muscle fibers resulting in the release of muscle fiber content into the circulation. Rhabdomyolysis from any cause leads to inadequate blood-perfusion and subsequent renal failure - cardiogenic shock or cardiorespiratory arrest may occur exceptionally.

The bald truth is that neuroleptic drugs are chemical lobotomizing agents with no specific therapeutic effect on any symptoms or regimens, and Stemetil is no exception. Neuroleptics (antipsychotics) inhibit dopamine nerve transmission in the frontal lobes and in the emotion-regulating limbic system of the brain. This inhibition is no different than surgical lobotomy. It is chemical lobotomy. Their main impact is to blunt and subdue the individual.. They also physically paralyze the body, rendering the individual less able to react or to move. Thus they act as a chemical lobotomy and a chemical straightjacket . In some cases these types of drug can physically paralyze the intestines, vital organs, including the inspiratory muscles of the diaphragm (diaphragmatic paralysis) literally smothering the patient, resulting in overwhelming exertional fatigue or stress , the panic fright factor response to chemical straightjacket, followed by a seemingly slow and painful death due cardiorespiratory arrest in the presence of circulatory collapse. Compare with the "locked-in state", a condition in which a person is conscious and able to think, but is severely paralyzed due to nerve paralysis. In my opinion which is widely shared, neuroleptic drugs should be banned.

Put yourself in such a patient's position of total or near total paralysis with most of your senses blunted, unable to move, speak or even open your eyes due to a severely paralyzed motor function - you try relentlessly to free yourseld until you become so overwhelmed by exhaustion, fright and panic that your heart begins to gives out. That's exactly what happened to Arlene Berry. But that that's not even the half of it. She became the victim of a horrific chain of medical negligence that is nothing short of criminal. No autopsy was performed. A family request for a formal inquest was also denied. The facts of the case, still under investigation together with the medical record can be viewed at:

This site is curently under construction.

www.meverett.com

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Introgenic Stemetil Poisoning.
by M.Emett Saturday August 20, 2005 at 02:04 PM
quatturodecillion@hotmail.com

Psychiatrists and Neuroleptic drugs are a regular
nightmare.Deleterious torturing techniques must dance in their heads.I read if someone in authority
told us to victimize and torture a so called patient
for the purpose of instituting a new medical technique,then 95% of us would have no objection
to doing that.That's what I call inhumanity gone wild in this creepy capitalism.
Yours Sincerely/(a patient)M. Svoboda.

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