Ÿ°¹±Ì ×ø³�äÖ �Ò:-
1.singlet oxygen
2.superperoxide
3.hydroxil
4.lipid peroxide

























Ÿ°¹±Ì ×ø³™�è ‡òé‘Ö ‡òî?

Ÿ°¹±Ì ×ø³™�è ‡òº³ »Ì‘«×‘É ‡ÍÉÅ þº‘³ …¯¥‘�Å �ÞÚ¿ —º‘Ϫ�è ‚�Å. µÅ …ÇÌ®™�è �æþ�‘÷’ÓϹ³ �â�¯¥ ×‘ì œ™±€Æ¿ —ºìÅ:-

�æþ�‘ø + »Ì‘«×‘É = ‡Í×‘É + ÿÑ + œ™± + Ÿ°¹±Ì ×ø³™�è

�®™�è ŠÏ ¶€ÒÆ‘î ¶€ÒÇÖ ƒÏ™� þׯ¨À‘î‘Ö,�³ Àíé �®™�æ¥ò þœÑ¹³,ŠÏ ºÌÀ‘®(molecule) צØÓÏ™�Å. …°‘Ì«Å:-
-O- ‡òé »Ì‘«×‘É �®, ƒÌ¯¨ H+ �®™�æ¥ò þœÑ¹³,H-O-H (H2O) ‡òé ºÌÀ‘®(molecule) ‚�ÚÅ, -O- ‡òé »Ì‘«×‘É �®, Àí—é‘Ï -O- �®Ú¥ò þœÑ¹³,O=O (O2) ‡òé ºÌÀ‘®(molecule) ‚�ÚÅ ¶€ÒÆ‘� ƒÏ™�Å.
»Ì‘«×‘É ‡ÍÉÅ þº‘³,€�€Æ™ �‘þ«‘Å �‘€Ò™ �‘þ«‘Å ‡òé ŠÏ ¶€ÒÇÖ ƒ¹° ºÌÀ‘®(molecule) ±�àÅ.ŠÏ ¿þÌ‘ªþ¥‘€î(proton) ƒÝ¹³, '—µ�§Ü œ‘Ñô' —�‘¯¥ ŠÏ ¶€ÒÆíé °ò€À€Æ¿ —ºìÅ.…°‘Ì«Å:- H-O-H (H2O) ‡òé ºÌÀ‘®(molecule) ŠÏ H+ ƒÝ¹³ OH-(hydroxyl) ‡òé ¶€ÒÇÕÅ, O=O (O2) ‡òé ºÌÀ‘®(molecule) ŠÏ O= ƒÝ¹³ O= (superoxide)‡òé ¶€ÒÇÕÅ, ƒÏ™�Å. ƒ°€î´ °‘ò µ‘Å Ÿ°¹±Ì ×ø³™�è ‡òì ˜ìŽþé‘Å.ƒ³ þº‘Ö Àíé Ÿ°¹±Ì ×ø³™�è 1O2(singlet oxygen),H2O2(hydrogen peroxide).


ŠÏ Ÿ°¹±Ì ×ø³ …ÇÌ®€×´ °‘™�Å
ŠÏ �íº€î¿ º¥Å.ŠÜ—×‘Ï …ÇÌ®™�€ãÉÅ
ŸÀ‘Ñ 10,000 °¥€× ƒ¿º¦ Ÿ°¹±Ì ×ø³™�è
þÀ‘³×°‘�¢ —œ‘ÖŽé‘Ñ�è!

Ÿ°¹±Ì ×ø³™�æ™� ‹Ñ Šíì€À ‡òî—×òé‘Ö �€€î´±ÕÅ »Ì‘«×‘É(oxygen) �® ƒÏ™�Å,'—µ�§Ü œ‘Ñô' —�‘¯¥ ŠÏ ¶€ÒÆíé °ò€ÀÇÖ ƒÏ™�Å.ƒ¹° ¶€ÒÇÖ ˆ°‘׳ Šòì¥ò ƒ€«Æ´ ³¦Æ‘´ ³¦™�Å.�¿º¦ ƒ€«ÉÅ þº‘³ �°€î ‚™÷’�Ì«Å(oxidation) ‡òì —œ‘ÖבÑ�è.ƒ¹° ƒ€«¿€º´ °¨™�Å ×ø³™� antioxidant �ÖÒ³ free radical scavangers (Ÿ°¹±Ì ×ø³ Øà›Ž) ‡òì —œ‘ÖבÑ�è!

Ÿ°¹±Ì ×ø³™�è ×Ó€À€Æ µ‘Å —°Í¹³ —�‘èã þׯ¨À‘î‘Ö,H2O2(hydrogen peroxide) ‡òé ±Ì×´€° ב›Ž, 2 —œ‘ª€¥ ŠÏ ³¬ÇÖ —º‘ª¥‘Ö —°ÍÉÅ---�¿º¦þÆ ³¬ —׿´³¿ þº‘ËØ¨Å.³¬™þ� ƒ¹° �±—Æòé‘Ö µÅ …ÇÌ®™�è ‡ÅÀ‘´±ÌÅ?

Ÿ°¹±Ì ×ø³�è(free radicals) µÅ …¥Å»Ö —œËÉÅ ²€À�è:-

µÀ³ ó“ò (gene) œÅº¹°¿ºª¥ DNA ‰ …ÇÑ �® �ÏØÖ(nucleous) þœ°¿º¨´³°Ö.

…ÇÑ �®™�€ã ŸíêÉèã œÜØÖ —�‘࿽ peroxidation ‰ �±�¿º¨´³°Ö.

.…ÇÑ �®™�äÖÕèã'‡ò€÷Å'�€ã ( enzymes) µ‘œ¿º¨´³°Ö.

Antioxidant ت¥Áò�ã‘î Øª¥Áò C, '¼ª¥‘ —�̪§ò'(ت¥Áò A) �ã€× …¥Å»Ö �€é´°Ö.

Low density lipoprotein —�‘à