Mt. Isarog is rich in biodiversity resources. Expeditions since 1961 recorded three rodents and a specie of blind snake that are found only in the park. In addition, the smallest falconet, the world's smallest raptor is endemic to Mt. Isarog.

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Mt. Isarog's flora is recorded close to 1,300 species in 1991 in a Botanical Survey conducted by Haribon Foundation - Mount Isarog National Park Conservation Project. Although much are still being determined for their endemicity, Mt. Isarog abounds of dipterocarps in the secondary lowland forests and pitcher plants, arborescent palms, oaks, mosses, liverworts, orchids, and ferns in the higher elevations.

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Floral species with the highest Density & Relative Density

List of Avifaunal species recorded within the RBI transect in Mt. Isarog National Park