The Hospital
1. Make your way over to the bell that Jill was unable to nudge (in the room with the triple statue puzzle) and push it out of the way. Head outside and use the explosive barrel to take out the pile of Zombies.
2. Enter the Hospital and prepare to meet an old friend (from RE1). Fight the two Hunters that arrear and grab the Red Herb x2 in the back of the room. Enter the save room, then grab the First Aid Spray and the Ink Ribbon x3 . Head out into the lounge area and grab the Blue Herb from the desk. Search the lockers to find Handgun Bullets x30 . On the table you'll find a Tape Recorder , which you'll need to use on the voice recognition lock near the elevator. Enter the elevator, and head down to B3.
3. Inside the lab area you'll find another soldier (he's a troubled soul). After the brief cut-scene, grab the Green Herb x2 and head through the door. Take the Medium Base and tun on the switch near the cultivation tank. Once it's activated, use the Medium Base to activate the puzzle. See the chart (below) for the quick switch solution. *1, 2, and A mean up. 3 and B mean down.*
4. You'll get the Vaccine Medium when you complete this puzzle. When you round the corner, the two Hunters will crack the glass containers and try to swallow you whole! Your best be is to run straight for the door and ignore them completely. Backtrack to the elevator and ride it up to 4F.
5. On the fourth floor, head to the Data Room, and take care of the two Hunters who reside there. Grab the Handgun Bullets x30 from the table and the Sickroom Key next to the experimental jars.
6. Head around the corner and enter the first door on your right. Inside, search the corpse to reveal a three digit (random) code. Write this down for use on the safe in the next room.
7. Use the Sickroom Key on the next door, and you'll be faced with an annoying puzzle. Basically, you'll need to take note of the exact location of the cart in the previous room (which plate was it on?). If it was in the top right corner, then you'll have to move the cart so that its in the top left corner. Once the safe opens, use the three digit code and get the Vaccine Base . Combine the Vaccine Medium with the Vaccine Base to make the Vaccine .
8. Blast the two Hunters into the netherworld and hop on the elevator down to 1F. Once there, a horde of Zombies will rush you, so use whatever remaining M-4 ammo that you have.
9. Run through the save room and into the main hallway where you'll find the bomb. You'll have six seconds to escape through the front door (plenty of time), or the bomb will go off and take you with it. Once clear of the building, backtrack all the way to Jill and administer the Vaccine. On the way back, you'll encounter the Nemesis as he pops through the ceiling on the main hallway in the Clock Tower. Just avoid him and keep moving, for gosh sake!