Homepage Introduction Secondary Structure Hydrophobicity of Papain Alignment of Papain against A. thaliana Papain compared to A. thaliana protein Homology Modeling Animated  Models Graphs and Spreadsheet           Structure Neighbors and 3D alignments for 1CVZ (papain) Chain A(Size=212)              A search for protein with similar structure to the of 1CVZ chain A was carried out. The result obtained ranged from 6.8% - 100% sequence similarity. 98.5 - 100% similarity was obtained with otherr cysteine proteinase obtained from Carica Papaya. However,since the objective is to check for sequence similarity in organisms other than Carica Papaya,only those are shown in table 1 below. ID Z-score RMSD(Å) Seq.(%) Aligned/size Gap Name Source 1CVZ:A QUERY - - - - Papain Carica Papaya                            (1) 1MEM:A 7.2  1.1 44.0 207/215 12 CathepsinK Kiwi Fruit or Chinese Gooseberry  (2) 2ACT 7.1 0.9 48.5 204/220 20 Actinidin Homo sapiens (3) 1F2C:A 7.1 1.2 36.5 203/215 19 Cruzain Trypanasoma cruzi  (4) 8PCH:A 7.1 1.4 42.6 202/233 21 Cathepsin H Sus scrofa(pig)                 (5)                                                                                                        Table: 1                                                                                                     GENE TREE ( 6) The tree was generated in Clustalw tool available at  EBI (7). SEQUENCE ALIGNMENT 3D STRUCTURAL ALIGNMENT OF 1CVZ(PAPAIN) WITH CATHEPSIN K (Fig.1 below)12 Fig. 1 3D STRUCTURAL ALIGNMENT OF 1CVZ(PAPAIN) WITH 2ACT(Fig.2 below)13                                                                                                 Fig. 2   3D STRUCTURAL ALIGNMENT OF ALL THE PROTEINS SHOWN IN TABLE 1 ABOVE(Fig.3 below)                  Fig.3                                                          PREVIOUS                                                                    NEXT